Electrochemical studies oxidation of ciprofloxacin at nano-SnO2/PVS modified electrode and its interaction with calf thymus DNA

被引：19

作者：

Cai, Yuejuan ^{[1
]}

Zhang, Yuzhong ^{[1
]}

Su, Shao ^{[1
]}

Li, Shuping ^{[1
]}

Ni, Yonghong ^{[1
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, Anhui Key Lab Funct Mol Solids, Wuhu 241000, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2007年 / 12卷

关键词：

ciprofloxacin; ctDNA; nano-SnO2; poly(Vinyl) sulfonic potassium; interaction;

D O I：

10.2741/2200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In pH 6.0 phosphate buffer solutions ( PBS), a glassy carbon electrode ( GCE) modifying by nano-tin oxide/ poly vinyl sulfonic potassium ( nano- SnO2/ PVS) exhibited an enhanced effectiveness for the oxidation of ciprofloxacin ( CFX), which compared with a bare GCE or a nano- SnO2 modified electrode. In addition we also investigated the electrooxidation mechanism of the fluoroquinolone antibiotics ( utilizing ciprofloxacin, ofloxacin, sparfloxacin and lomefloxacin) at the modified electrode. Further more, Gel electrophoresis coupled with electrochemistry and spectra techniques were used to study the interaction of CFX and calf thymus DNA ( ctDNA). These acquired data showed that the binding mode of CFX and DNA was mainly an intercalation mechanism.

引用

页码：1946 / 1955

页数：10

共 38 条

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