Hypoxic Regulation of Neutrophils in Cancer

被引：13

作者：

Triner, Daniel ^{[1
]}

Shah, Yatrik M. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 17期

关键词：

neutrophil; hypoxia; HIF; cancer; TUMOR-ASSOCIATED NEUTROPHILS; INDUCIBLE FACTORS; SUPPRESSOR-CELLS; PROMOTE COLITIS; MOUSE MODEL; T-CELLS; INFLAMMATION; HIF-1-ALPHA; CARCINOMA; BLOCKADE;

D O I：

10.3390/ijms20174189

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating neutrophil function in tumors. Furthermore, neutrophil-specific expression of hypoxia-inducible transcription factors may represent a novel therapeutic target for human cancer. In this review, we highlight the function of neutrophils in cancer and the role of the neutrophil hypoxic response in regulating the neoplastic progression of cancer.

引用

页数：12

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