Synthesis and Fungicidal Activities of 2-Substituted-4-methyl-5-aryl-2H-1,2,3-triazole Derivatives

A series of 2-substituted-4-methyl-5-aryl-2H-1,2,3-triazoles was synthesized using aromatic aldehyde, nitroethane, and sodium azide as the starting materials in the yield of 56-96%. The structures of title compounds were characterized by nuclear magnetic resonance, mass spectrometry, and elemental analyses. All of the target compounds were evaluated in vitro for their fungicidal activity against Gibberella zeae, Phytophthora capsici, Alternaria alternate, Botrytis cinerea, Rhizoctonia solani, and Sclerotinia sclerotiorum at a concentration of 25 mg/L. The bio-assay results revealed that most of the compounds had preliminary fungicidal activity against G. zeae, P. capsici, and A. alternate. Among them, the inhibitory rate of compound 3b to Phytophthora capsici was up to 82.0%.