Calcium signalling and breast cancer

被引：63
作者：
So, Choon Leng [1 ]
Saunus, Jodi M. [2 ]
Roberts-Thomson, Sarah J. [1 ]
Monteith, Gregory R. [1 ,3 ]
机构：
[1] Univ Queensland, Sch Pharm, Woolloongabba, Qld 4102, Australia
[2] Univ Queensland, Fac Med, UQ Ctr Clin Res, Herston, Qld 4029, Australia
[3] Univ Queensland, Translat Res Inst, Mater Res Inst, Woolloongabba, Qld 4102, Australia
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2019年 / 94卷
基金：
英国医学研究理事会;
关键词：
Breast cancer; Calcium; Calcium signalling; Cancer; ORAI channels; TRP channels; TO-MESENCHYMAL TRANSITION; CELL-CYCLE PROGRESSION; PLASMA-MEMBRANE; ION-CHANNEL; ENDOPLASMIC-RETICULUM; CA2+ INFLUX; MITOCHONDRIAL CA2+; GENE-EXPRESSION; DOWN-REGULATION; INHIBITOR;
D O I：
10.1016/j.semcdb.2018.11.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The past two decades have seen the identification of important roles for calcium signalling in many of the hallmarks of cancer. One of the cancer types that has been a particular focus of such studies is breast cancer. The breast is intrinsically linked to the calcium ion due to the importance of milk calcium in neonatal growth and development. Indeed, some of the calcium channels and pumps involved in transporting calcium ions into milk also have altered expression in some breast cancers. However, altered expression is not confined to channels and pumps important in lactation, other calcium channels and pumps may also be modulated and may even be specific to breast cancer molecular subtypes. This review considers calcium signalling in the context of breast cancer and provides an overview of the roles that have been attributed to specific regulators of cellular calcium levels in processes relevant to breast cancer progression. Emerging areas in the study of calcium signalling in breast cancer are considered, such as the intersection between calcium signalling, the tumour microenvironment and breast cancer.
引用
收藏
页码：74 / 83
页数：10
相关论文
共 126 条
[1]   Integration of Ca2+ signaling regulates the breast tumor cell response to simvastatin and doxorubicin [J].
Abdoul-Azize, Souleymane ;
Buquet, Catherine ;
Li, Hong ;
Picquenot, Jean-Michel ;
Vannier, Jean-Pierre .
ONCOGENE, 2018, 37 (36) :4979-4993
[2]   Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy [J].
Adapala, R. K. ;
Thoppil, R. J. ;
Ghosh, K. ;
Cappelli, H. C. ;
Dudley, A. C. ;
Paruchuri, S. ;
Keshamouni, V. ;
Klagsbrun, M. ;
Meszaros, J. G. ;
Chilian, W. M. ;
Ingber, D. E. ;
Thodeti, C. K. .
ONCOGENE, 2016, 35 (03) :314-322
[3]   Molecular Pathways: Involvement of Immune Pathways in the Therapeutic Response and Outcome in Breast Cancer [J].
Andre, Fabrice ;
Dieci, Maria V. ;
Dubsky, Peter ;
Sotiriou, Christos ;
Curigliano, Giuseppe ;
Denkert, Carsten ;
Loi, Sherene .
CLINICAL CANCER RESEARCH, 2013, 19 (01) :28-33
[4]  
Azimi I., 2018, CELL MOL LIFE SCI
[5]   TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells [J].
Azimi, Iman ;
Milevskiy, Michael J. G. ;
Kaemmerer, Elke ;
Turner, Dane ;
Yapa, Kunsala T. D. S. ;
Brown, Melissa A. ;
Thompson, Erik W. ;
Roberts-Thomson, Sarah J. ;
Monteith, Gregory R. .
JOURNAL OF CELL SCIENCE, 2017, 130 (14) :2292-2305
[6]  
Badaoui Mehdi, 2018, Oncotarget, V9, P24653, DOI 10.18632/oncotarget.19065
[7]   Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells [J].
Baggott, Rhiannon R. ;
Mohamed, Tamer M. A. ;
Oceandy, Delvac ;
Holton, Marylouisa ;
Blanc, Marie Cecile ;
Roux-Soro, Sandrine C. ;
Brown, Sarah ;
Brown, James E. ;
Cartwright, Elizabeth J. ;
Wang, Weiguang ;
Neyses, Ludwig ;
Armesilla, Angel L. .
CARCINOGENESIS, 2012, 33 (12) :2362-2368
[8]   Assessment of cytosolic free calcium changes during ceramide-induced cell death in MDA-MB-231 breast cancer cells expressing the calcium sensor GCaMP6m [J].
Bassett, John J. ;
Bong, Alice H. L. ;
Janke, Ellen K. ;
Robitaille, Melanie ;
Roberts-Thomson, Sarah J. ;
Peters, Amelia A. ;
Monteith, Gregory R. .
CELL CALCIUM, 2018, 72 :39-50
[9]   Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression [J].
Bissell, Mina J. ;
Hines, William C. .
NATURE MEDICINE, 2011, 17 (03) :320-329
[10]   The role of TRPV6 in breast carcinogenesis [J].
Bolanz, Katrin A. ;
Hediger, Matthias A. ;
Landowski, Christopher P. .
MOLECULAR CANCER THERAPEUTICS, 2008, 7 (02) :271-279
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