Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia muciniphila as a Key Gut Bacterium

被引：105

作者：

Aron, Raluca Anca Corb ^{[1
]}

Abid, Areha ^{[2
]}

Vesa, Cosmin Mihai ^{[1
]}

Nechifor, Aurelia Cristina ^{[3
]}

Behl, Tapan ^{[4
]}

Ghitea, Timea Claudia ^{[5
]}

Munteanu, Mihai Alexandru ^{[6
]}

Fratila, Ovidiu ^{[6
]}

Andronie-Cioara, Felicia Liana ^{[7
]}

Toma, Mirela Marioara ^{[5
]}

Bungau, Simona ^{[5
]}

机构：

[1] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania

[2] Univ Debrecen, Fac Agr & Food Sci, Dept Food Sci, H-4032 Debrecen, Hungary

[3] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Analyt Chem, Bucharest 011061, Romania

[4] Chitkara Univ, Chitkara Coll Pharm, Dept Pharmacol, Rajpura 140401, Punjab, India

[5] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania

[6] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania

[7] Univ Oradea, Fac Med & Pharm, Dept Psychoneurosci & Recovery, Oradea 410073, Romania

来源：

MICROORGANISMS | 2021年 / 9卷 / 03期

关键词：

prebiotics; probiotics; metabolic syndrome; type 2 diabetes mellitus; Akkermansia muciniphila; gut bacterium; HIGH-FAT DIET; IN-VITRO FERMENTATION; NECROSIS-FACTOR-ALPHA; DOUBLE-BLIND; BLOOD-PRESSURE; LIPID PROFILE; INSULIN-RESISTANCE; INDUCED OBESITY; INTESTINAL MICROBIOTA; GLYCEMIC CONTROL;

D O I：

10.3390/microorganisms9030618

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) are diseases that can be influenced by the structure of gut microbiota, whose improvement is often neglected in metabolic pathology. This review highlights the following main aspects: the relationship between probiotics/gut microbes with the pathogenesis of MetS, the particular positive roles of Akkermansia muciniphila supplementation in the onset of MetS, and the interaction between dietary polyphenols (prebiotics) with gut microbiota. Therefore, an extensive and in-depth analysis of the often-neglected correlation between gut microbiota and chronic metabolic diseases was conducted, considering that this topic continues to fascinate and stimulate researchers through the discovery of novel strains and their beneficial properties.

引用

页码：1 / 32

页数：31

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