Spontaneous Control of Viral Replication during Primary HIV Infection: When Is "HIV Controller" Status Established?

被引：70

作者：

Goujard, Cecile ^{[1
,2
]}

Chaix, Marie-Laure ^{[3
]}

Lambotte, Olivier ^{[1
,2
]}

Deveau, Christiane ^{[4
]}

Sinet, Martine ^{[2
]}

Guergnon, Julien ^{[5
]}

Courgnaud, Valerie ^{[6
]}

Rouzioux, Christine ^{[3
]}

Delfraissy, Jean-Francois ^{[1
,2
]}

Venet, Alain ^{[2
]}

Meyer, Laurence ^{[4
]}

机构：

[1] Hop Bicetre, AP HP, Serv Med Interne, F-94275 Le Kremlin Bicetre, France

[2] Univ Paris Sud, INSERM, U802, F-94275 Le Kremlin Bicetre, France

[3] Univ Paris 05, Virol Lab, Equipe Accueil Minist Rech & Technol 3620, Hop Necker Enfants Malades,AP HP, Paris, France

[4] Univ Paris Sud, INSERM, Serv Epidemiol & Sante Publ, AP HP,U822, F-94275 Le Kremlin Bicetre, France

[5] Univ Paris 06, INSERM, Hop La Pitie Salpetriere, AP HP,U543, Paris, France

[6] CHU Montpellier, Virol Lab, Ctr Natl Rech Sci, UMR 5535, Montpellier, France

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 06期

关键词：

CD8(+) T-CELLS; DISEASE PROGRESSION; TYPE-1; INFECTION; IMMUNE CONTROL; VIRUS CONTROL; DNA; SEROCONVERTERS; ASSOCIATION; THERAPY; ALLELES;

D O I：

10.1086/605504

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Eight patients in the ANRS PRIMO cohort experienced early spontaneous viral control. Viral control was established a median of 6.2 months after primary human immunodeficiency virus type 1 infection and lasted a median of 4.1 years. Seven of the patients initially had detectable viral replication. For 4 patients, viral control was lost during follow-up.

引用

页码：982 / 986

页数：5

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