Predictive Value of Blood Coagulation Parameters in Poor Outcomes in COVID-19 Patients: A Retrospective Observational Study in Romania

被引:19
作者
Citu, Cosmin [1 ]
Burlea, Bogdan [2 ]
Gorun, Florin [1 ]
Motoc, Andrei [3 ]
Gorun, Oana Maria [2 ]
Malita, Daniel [4 ]
Ratiu, Adrian [1 ]
Margan, Roxana [5 ]
Grigoras, Mirela Loredana [3 ]
Bratosin, Felix [6 ]
Citu, Ioana Mihaela [7 ]
机构
[1] Victor Babes Univ Med & Pharm, Dept Obstet & Gynecol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[2] Municipal Emergency Clin Hosp Timisoara, Dept Obstet & Gynecol, 1-3 Alexandru Odobescu St, Timisoara 300202, Romania
[3] Victor Babes Univ Med & Pharm, Dept Anat & Embryol, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
[4] Victor Babes Univ Med & Pharm, Dept Radiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania
[5] Victor Babes Univ Med & Pharm, Ctr Studies Prevent Med, Discipline Hyg, Dept Microbiol 14, Timisoara 300041, Romania
[6] Victor Babes Univ Med & Pharm, Methodol & Infect Dis Res Ctr, Dept Infect Dis, Timisoara 300041, Romania
[7] Victor Babes Univ Med & Pharm, Dept Internal Med 1, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
关键词
COVID-19; coagulation; prediction;
D O I
10.3390/jcm11102831
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
SARS-CoV-2 infection produces alterations in blood clotting, especially in severe cases of COVID-19. Abnormal coagulation parameters in patients with COVID-19 are important prognostic factors of disease severity. The objective of this study was to evaluate the predictive value of aPTT, D-dimer, INR and PT in the mortality of patients with COVID-19. A retrospective, single-center, observational study was conducted on COVID-19 patients admitted to the Municipal Emergency Clinical Hospital in Timisoara, Romania, between August and October 2021. Patients were confirmed as COVID-19 positive by reverse transcription-polymerase chain reaction (RT-PCR) assay. After applying the inclusion/exclusion criteria, a total of 82 patients were included in the analysis. Receiver operating characteristic (ROC) curves of D-Dimer, INR, PT and aPTT were generated to assess whether the baseline of each of these biomarkers was accurately predictive for mortality in patients with COVID-19. Mortality among patients enrolled in this study was 20.7%, associated with older age and presence of heart disease. The areas under the ROC curve (AUC-ROC) of D-Dimer, INR, PT, and aPTT were 0.751, 0.724, 0.706 and 0.753. Differences in survival for patients with coagulation biomarker levels above cut-off values compared to patients below these values were statistically significant. All evaluated parameters had significant differences and good performance in predicting mortality of COVID-19 patients, except fibrinogen, which had no significant difference. Moreover, aPTT and D-dimer were the best performing parameters in predicting mortality in patients with SARS-CoV-2 infection.
引用
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页数:8
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