Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

被引：121

作者：

Codella, Roberto ^{[1
,2
]}

Luzi, Livio ^{[1
,2
]}

Terruzzi, Ileana ^{[3
]}

机构：

[1] Univ Milan, Dept Biomed Sci Hlth, Via Flli Cervi 93, I-20090 Milan, Italy

[2] IRCCS Policlin San Donato, Metab Res Ctr, San Donato Milanese, Italy

[3] Ist Sci San Raffaele, Metab Nutrigen & Cellular Differentiat Unit, Diabet Res Inst, Milan, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2018年 / 50卷 / 04期

关键词：

Exercise; Gut microbiota; Type; 1; diabetes; INTESTINAL BARRIER DYSFUNCTION; INFLAMMATORY-BOWEL-DISEASE; DIET-INDUCED OBESITY; MODERATE EXERCISE; TNF-ALPHA; CARDIORESPIRATORY FITNESS; RUNNING EXERCISE; SKELETAL-MUSCLE; MOUSE; VOLUNTARY;

D O I：

10.1016/j.dld.2017.11.016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Limited animal and human research findings suggests that exercise might have a beneficial role for health gut. Cardiorespiratory fitness correlates with health-associated gut parameters such as taxonomic diversity and richness. Physical exercise may augment intestinal microbial diversity through several mechanisms including promotion of an anti-inflammatory state. Disease-associated microbial functions were linked to distinct taxa in previous studies of familial type 1 diabetes mellitus (T1D). An integrated multi-approach in the study of T1D, including physical exercise, is advocated. The present review explores how exercise might modulate gut microbiota and microbiome characteristics in chronic and immune based diseases, given the demonstrated relationship between gut function and human health. (C) 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：331 / 341

页数：11

共 129 条

[1] Active Subjects With Autoimmune Type 1 Diabetes Have Better Metabolic Profiles Than Sedentary Controls [J].

Adamo, M. ;

Codella, R. ;

Casiraghi, F. ;

Ferrulli, A. ;

Macri, C. ;

Bazzigaluppi, E. ;

Terruzzia, I. ;

Inverardi, L. ;

Ricordi, C. ;

Luzi, L. .

CELL TRANSPLANTATION, 2017, 26 (01) :23-32

[2] Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J mice [J].

Allen, Jacob M. ;

Miller, Margret E. Berg ;

Pence, Brandt D. ;

Whitlock, Keith ;

Nehra, Vandana ;

Gaskins, H. Rex ;

White, Bryan A. ;

Fryer, John D. ;

Woods, Jeffrey A. .

JOURNAL OF APPLIED PHYSIOLOGY, 2015, 118 (08) :1059-1066

[3] The NOD mouse: A model of immune dysregulation [J].

Anderson, MS ;

Bluestone, JA .

ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 :447-485

[4]

[Anonymous], 2015, INF SHEET GLOB REC P

[5]

[Anonymous], 2010, GLOB REC PHYS ACT HL

[6]

[Anonymous], 2010, DIABETES CARE

[7] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice [J].

Backhed, Fredrik ;

Manchester, Jill K. ;

Semenkovich, Clay F. ;

Gordon, Jeffrey I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :979-984

[8] Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight toss [J].

Balducci, S. ;

Zanuso, S. ;

Nicolucci, A. ;

Fernando, F. ;

Cavallo, S. ;

Cardelli, P. ;

Fallucca, S. ;

Alessi, E. ;

Letizia, C. ;

Jimenez, A. ;

Fallucca, F. ;

Pugliese, G. .

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2010, 20 (08) :608-617

[9] The role of Gut Microbiota in the development of obesity and Diabetes [J].

Baothman, Othman A. ;

Zamzami, Mazin A. ;

Taher, Ibrahim ;

Abubaker, Jehad ;

Abu-Farha, Mohamed .

LIPIDS IN HEALTH AND DISEASE, 2016, 15

[10]

Barton W, 2017, GUT

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