Comparison of nitroglycerin lingual spray and sublingual tablet on time of onset and duration of brachial artery vasodilation in normal subjects

被引：60
作者：
Ducharme, A [1 ]
Dupuis, J [1 ]
McNicoll, S [1 ]
Harel, F [1 ]
Tardif, JC [1 ]
机构：
[1] Montreal Heart Inst, Res Ctr, Dept Med, Div Cardiol, Montreal, PQ H1T 1C8, Canada
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 1999年 / 84卷 / 08期
关键词：
D O I：
10.1016/S0002-9149(99)00478-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study compared the rapidity of onset, the magnitude, and the duration of action of 2 shore-acting nitroglycerin preparations using high-resolution brachial ultrasound. Both sublingual tablet and lingual spray formulations caused maximal vasodilation at 3 minutes; however, the spray provided faster (at 2 minutes), greater, and more prolonged (15 minutes) vasodilation than the tablet.
引用
收藏
页码：952 / +
页数：4
相关论文
共 11 条
  • [1] CLOSE RELATION OF ENDOTHELIAL FUNCTION IN THE HUMAN CORONARY AND PERIPHERAL CIRCULATIONS
    ANDERSON, TJ
    UEHATA, A
    GERHARD, MD
    MEREDITH, IT
    KNAB, S
    DELAGRANGE, D
    LIEBERMAN, EH
    GANZ, P
    CREAGER, MA
    YEUNG, AC
    SELWYN, AP
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1995, 26 (05) : 1235 - 1241
  • [2] BLOOD-LEVELS AFTER SUB-LINGUAL NITROGLYCERIN
    ARMSTRONG, PW
    ARMSTRONG, JA
    MARKS, GS
    [J]. CIRCULATION, 1979, 59 (03) : 585 - 588
  • [3] CLINICAL PHARMACOKINETICS OF NITRATES
    BOGAERT, MG
    [J]. CARDIOVASCULAR DRUGS AND THERAPY, 1994, 8 (05) : 693 - 699
  • [4] NONINVASIVE DETECTION OF ENDOTHELIAL DYSFUNCTION IN CHILDREN AND ADULTS AT RISK OF ATHEROSCLEROSIS
    CELERMAJER, DS
    SORENSEN, KE
    GOOCH, VM
    SPIEGELHALTER, DJ
    MILLER, OI
    SULLIVAN, ID
    LLOYD, JK
    DEANFIELD, JE
    [J]. LANCET, 1992, 340 (8828) : 1111 - 1115
  • [5] GLANTZ SA, 1981, PRIMER BIOSTATISTICS, P88
  • [6] REISIN LH, 1988, AM J CARDIOL, V61, pE2
  • [7] Sato H, 1997, ARZNEIMITTEL-FORSCH, V47, P128
  • [8] SCHNEEWEISS A, 1986, DRUG THERAPY CARDIOV, P5
  • [9] VANDENBURG MJ, 1986, BRIT J CLIN PRACT, V40, P524
  • [10] WIGHT LJ, 1992, EUR J CLIN PHARMACOL, V42, P341
12