Tumour immunology: T cells work together to fight cancer

被引：9

作者：

Cerundolo, V ^{[1
]}

机构：

[1] Inst Mol Med, Nuffield Dept Med, Oxford OX3 9DS, England

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 18期

关键词：

D O I：

10.1016/S0960-9822(99)80442-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have identified new melanoma antigens that are recognised by CD4(+) T cells. Analysis of tumour-specific CD4(+) T-cell responses may lead to the development of optimal anti-cancer vaccines that can induce an orchestrated effort of tumour-specific CD4(+) and CD8(+) T cells in the fight against cancer.

引用

页码：R695 / R697

页数：3

共 16 条

[1] Identification of MAGE-3 epitopes presented by HLA-DR molecules to CD4+ T lymphocytes [J].

Chaux, P ;

Vantomme, V ;

Stroobant, V ;

Thielemans, K ;

Corthals, J ;

Luiten, R ;

Eggermont, AMM ;

Boon, T ;

van der Bruggen, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :767-777

[2] IDENTIFICATION OF A PEPTIDE RECOGNIZED BY 5 MELANOMA-SPECIFIC HUMAN CYTOTOXIC T-CELL LINES [J].

COX, AL ;

SKIPPER, J ;

CHEN, Y ;

HENDERSON, RA ;

DARROW, TL ;

SHABANOWITZ, J ;

ENGELHARD, VH ;

HUNT, DF ;

SLINGLUFF, CL .

SCIENCE, 1994, 264 (5159) :716-719

[3] A receptor for the selective uptake and degradation of proteins by lysosomes [J].

Cuervo, AM ;

Dice, JF .

SCIENCE, 1996, 273 (5274) :501-503

[4] ROLE OF BONE-MARROW-DERIVED CELLS IN PRESENTING MHC CLASS I-RESTRICTED TUMOR-ANTIGENS [J].

HUANG, AYC ;

GOLUMBEK, P ;

AHMADZADEH, M ;

JAFFEE, E ;

PARDOLL, D ;

LEVITSKY, H .

SCIENCE, 1994, 264 (5161) :961-965

[5] The central role of CD4+ T cells in the antitumor immune response [J].

Hung, K ;

Hayashi, R ;

Lafond-Walker, A ;

Lowenstein, C ;

Pardoll, D ;

Levitsky, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2357-2368

[6] Immunology - Licence to kill [J].

Lanzavecchia, A .

NATURE, 1998, 393 (6684) :413-414

[7] Melanoma cells present a MAGE-3 epitope to CD4+ cytotoxic T cells in association with histocompatibility leukocyte antigen DR11 [J].

Manici, S ;

Sturniolo, T ;

Imro, MA ;

Hammer, J ;

Sinigaglia, F ;

Noppen, C ;

Spagnoli, G ;

Mazzi, B ;

Bellone, M ;

Dellabona, P ;

Protti, MP .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :871-876

[8] CLASS-II MHC MOLECULES CAN USE THE ENDOGENOUS PATHWAY OF ANTIGEN PRESENTATION [J].

NUCHTERN, JG ;

BIDDISON, WE ;

KLAUSNER, RD .

NATURE, 1990, 343 (6253) :74-76

[9] New paths in human cancer serology [J].

Old, LJ ;

Chen, YT .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (08) :1163-1167

[10] Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors [J].

Ossendorp, F ;

Mengedé, E ;

Camps, M ;

Filius, R ;

Melief, CJM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (05) :693-702

← 1 2 →