pH-sensitive liposomes for colonic co-delivery of mesalazine and curcumin for the treatment of ulcerative colitis

被引:21
作者
Aib, Soumayya [1 ]
Iqbal, Kashif [1 ]
Khan, Nasir [1 ]
Khalid, Sidra [2 ]
Adnan, Muhammad [1 ]
Umair, Syed Muhammad [3 ]
Dar, M. Junaid [1 ,4 ]
机构
[1] IBADAT Int Univ, Sch Pharm, Nanomed Res Grp, Islamabad 44000, Pakistan
[2] Drug Regulatory Author Pakistan DRAP, Div Pharmaceut Evaluat & Registrat, Islamabad 04491, Pakistan
[3] Univ Arid Agr, Fac Vet & Anim Sci, Dept DVM, Rawalpindi 46300, Pakistan
[4] IBADAT Int Univ, Sch Pharm, Islamabad 44000, Pakistan
关键词
Ulcerative colitis; Liposome; pH sensitive approach; Colon targeting drug delivery; Mesalazine; Curcumin; DRUG-DELIVERY; CYTOKINES;
D O I
10.1016/j.jddst.2022.103335
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The ineffectiveness of the current management of ulcerative colitis (UC) demands novel pharmaceutical techniques and advance therapeutic strategies to facilitate safe and efficacious treatment of the disease. In this quest, mesalazine (MZ), a 5-aminosalicylate with anti-inflammatory and potent antioxidant activities, along with curcumin (CM), a natural anti-inflammatory and antioxidant polyphenol, were found to produce a synergistic efficacy to efficiently alleviate UC. In the present study, we have formulated pH-sensitive liposomes (LS) containing a low-dose combination of MZ and CM as a potential therapy for UC. It was hypothesized that the synergistic action of the two drugs, pH-dependent colon-specific delivery, and use of LS as a nano-technological drug carrier system could diminish drug-associated side effects, reduce the dose and provide effective treatment strategy for UC. The guinea pig model of UC was used to evaluate the in vivo efficacy of pH sensitive MZ-CM coloaded LS and found to be more efficacious than single-drug LS or drug solution. Furthermore, both drugs exhibited high antioxidant activity and mitigated the oxidative stress present along UC; resulting in an effective treatment of UC. In conclusion, eudragit-S100 coated MZ-CM liposomes is a promising treatment strategy for the effective oral therapy of UC.
引用
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页数:8
相关论文
共 18 条
[1]   Thin-film hydration preparation method and stability test of DOX-loaded disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate nanomicelles [J].
Ai, Xiaoyu ;
Zhong, Lu ;
Niu, Handong ;
He, Zhonggui .
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 9 (05) :244-250
[2]  
Daar J, 2017, PAK J PHARM SCI, V30, P601
[3]  
Dar M.J, 2019, MAT BIOMEDICAL ENG, P215
[4]   Nano-elastic liposomes as multidrug carrier of sodium stibogluconate and ketoconazole: A potential new approach for the topical treatment of cutaneous Leishmaniasis [J].
Dar, M. Junaid ;
Khalid, Sidra ;
Varikuti, Sanjay ;
Satoskar, Abhay R. ;
Khan, Gul Majid .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 145
[5]   Development and evaluation of novel miltefosine-polyphenol co-loaded second generation nano-transfersomes for the topical treatment of cutaneous leishmaniasis [J].
Dar, M. Junaid ;
McElroy, Craig A. ;
Khan, Muhammad Ijaz ;
Satoskar, Abhay R. ;
Khan, Gul Majid .
EXPERT OPINION ON DRUG DELIVERY, 2020, 17 (01) :97-110
[6]   Topical treatment of cutaneous leishmaniasis with novel amphotericin B-miltefosine co-incorporated second generation ultra-deformable liposomes [J].
Dar, M. Junaid ;
Khalid, Sidra ;
McElroy, Craig A. ;
Satoskar, Abhay R. ;
Khan, Gul Majid .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 573
[7]   Sodium stibogluconate loaded nano-deformable liposomes for topical treatment of leishmaniasis: macrophage as a target cell [J].
Dar, M. Junaid ;
Din, Fakhar Ud ;
Khan, Gul Majid .
DRUG DELIVERY, 2018, 25 (01) :1595-1606
[8]   Polymer-based drug delivery: the quest for local targeting of inflamed intestinal mucosa [J].
Dar, M. Junaid ;
Ali, Hussain ;
Khan, Amjad ;
Khan, Gul Majid .
JOURNAL OF DRUG TARGETING, 2017, 25 (07) :582-596
[9]   Zeaxanthin exerts protective effects on acetic acid-induced colitis in rats via modulation of pro-inflammatory cytokines and oxidative stress [J].
El-Akabawy, Gehan ;
El-Sherif, Neveen M. .
BIOMEDICINE & PHARMACOTHERAPY, 2019, 111 :841-851
[10]   Surfactant free synthesis of cationic nano-vesicles: A safe triple drug loaded vehicle for the topical treatment of cutaneous leishmaniasis [J].
Khalid, Sidra ;
Salman, Saad ;
Iqbal, Kashif ;
Rehman, Fiza Ur ;
Ullah, Iffat ;
Satoskar, Abhay R. ;
Khan, Gul Majid ;
Dar, M. Junaid .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2022, 40