Kinetic resolution of (±)-2-methyl-1,2,3,4-tetrahydroquinoline and (±)-2-methylindoline

被引：32

作者：

Krasnov, VP ^{[1
]}

Levit, GL ^{[1
]}

Andreeva, IN ^{[1
]}

Grishakov, AN ^{[1
]}

Charushin, VN ^{[1
]}

Chupakhin, ON ^{[1
]}

机构：

[1] Russian Acad Sci, Urals Branch, Inst Organ Synth, Ekaterinburg 620219, Russia

来源：

MENDELEEV COMMUNICATIONS | 2002年 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1070/MC2002v012n01ABEH001545

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The acylation of racemic 2-methyl-1,2,3,4-tetrahydroquinotine and 2-methylindoline by (S)-naproxen acyl chloride resulted in their kinetic resolution with the predominant formation of (S,S)-diastereoisomeric amides (de 78-76%), recrystallisation of which followed by acid hydrolysis gave individual (S)-isomers of heterocyclic amines.

引用

页码：27 / 28

页数：2

共 3 条

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NOYORI, R ;

TOKUNAGA, M ;

KITAMURA, M .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1995, 68 (01) :36-55

[3] SYNTHESIS OF PEPTIDES CONTAINING 1,2,3,4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID .1. ABSOLUTE-CONFIGURATIONS OF 1,2,3,4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS AND 2-SUBSTITUTED 1,2,3,4-TETRAHYDROQUINOLINES [J].

PARADISI, MP ;

ROMEO, A .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1977, (06) :596-600

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