Immunotherapeutic Approach for Better Management of Cancer - Role of IL-18

被引：17

作者：

Kuppala, Manohar Babu

Syed, Sunayana Begum

Bandaru, Srinivas

Varre, Sreedevi

Akka, Jyothy

Mundulru, Hema Prasad ^{[1
]}

机构：

[1] Osmania Univ, Inst Genet, Hyderabad 500007, Andhra Pradesh, India

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷 / 11期

关键词：

Interleukin-18; cancer; angiogenesis; immunotherapy; predictive marker; PROMOTER GENE POLYMORPHISMS; INTERFERON-GAMMA PRODUCTION; ENDOTHELIAL GROWTH-FACTOR; HUMAN GASTRIC-CANCER; INTERLEUKIN-18; GENE; SERUM INTERLEUKIN-18; MALIGNANT-MELANOMA; IMMUNE ESCAPE; LUNG-CANCER; EXPRESSION;

D O I：

10.7314/APJCP.2012.13.11.5353

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-18 (IL-18) is an immune-stimulatory cytokine with antitumor activity in preclinical models. It plays pivotal roles in linking inflammatory immune responses and tumor progression and is a useful candidate in gene therapy of lymphoma or lymphoid leukemia. A phase I study of recombinant human IL-18 (rhIL-18) in patients with advanced cancer concluded that rhIL-18 can be safely given in biologically active doses to patients with advanced cancer. Some viruses can induce the secretion of IL-18 for immune evasion. The individual cytokine activity might be potentiated or inhibited by combinations of cytokines. Here we focus on combinational effects of cytokines with IL-18 in cancer progression. IL-18 is an important non- invasive marker suspected of contributing to metastasis. Serum IL-18 may a useful biological marker as independent prognostic factor of survival. In this review we cover roles of IL-18 in immune evasion, metastasis and angiogenesis, applications for chemotherapy and prognostic or diagnostic significance.

引用

页码：5353 / 5361

页数：9

共 92 条

[1] Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemoimmunotherapy [J].