AGGREGATION-PRONE PROTEINS EXACERBATE HUNTINGTIN TOXICITY IN YEAST AND DROSOPHILA

被引：0
|
作者：
Branco dos Santos, J. [1 ,2 ]
Staniforth, G. [4 ]
Breda, C. [2 ]
Herrera, F. [1 ]
Outeiro, T. F. [1 ,3 ]
Tuite, M. [4 ]
Giorgini, F. [2 ]
机构：
[1] Univ Lisbon, Inst Med Mol, Fac Med, P-1649028 Lisbon, Portugal
[2] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England
[3] Univ Med Ctr Goettingen, Dept Neurodegenerat & Restorat Res, D-37073 Gottingen, Germany
[4] Univ Kent, Sch Biosci, Canterbury CT2 7NJ, Kent, England
来源：
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2014年 / 85卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1136/jnnp-2014-309032.35
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
B07
引用
收藏
页码：A11 / A11
页数：1
相关论文
共 50 条
  • [1] Predicting aggregation-prone sequences in proteins
    De Baets, Greet
    Schymkowitz, Joost
    Rousseau, Frederic
    AMYLOIDS IN HEALTH AND DISEASE, 2014, 56 : 41 - 52
  • [2] Prediction of aggregation-prone regions in structured proteins
    Tartaglia, Gian Gaetano
    Pawar, Amol P.
    Campioni, Silvia
    Dobson, Christopher M.
    Chiti, Fabrizio
    Vendruscolo, Michele
    JOURNAL OF MOLECULAR BIOLOGY, 2008, 380 (02) : 425 - 436
  • [3] A comparison of the aggregation of different CFTR-derived peptides, the N-terminal huntingtin fragments and different fusion proteins encompassing the aggregation-prone sequences of CFTR and/or huntingtin
    Bak, D
    Jurkowska, M
    Dolowy, K
    Milewski, M
    FEBS JOURNAL, 2005, 272 : 364 - 365
  • [4] Imaging-based approaches to the aggregation-prone mutant huntingtin protein in cellular contexts
    Sahl, S. J.
    Vonk, W. I. M.
    Weiss, L. E.
    Lau, L.
    Frydman, J.
    Moerner, W. E.
    FEBS JOURNAL, 2014, 281 : 32 - 32
  • [5] Translationally optimal codons associate with aggregation-prone sites in proteins
    Lee, Yaelim
    Zhou, Tong
    Tartaglia, Gian Gaetano
    Vendruscolo, Michele
    Wilke, Claus O.
    PROTEOMICS, 2010, 10 (23) : 4163 - 4171
  • [6] A Consensus Method for the Prediction of 'Aggregation-Prone' Peptides in Globular Proteins
    Tsolis, Antonios C.
    Papandreou, Nikos C.
    Iconomidou, Vassiliki A.
    Hamodrakas, Stavros J.
    PLOS ONE, 2013, 8 (01):
  • [7] Short Aggregation-Prone Peptide Detectives: Finding Proteins and Truths about Aggregation
    Mittag, Tanja
    Marzahn, Melissa R.
    JOURNAL OF MOLECULAR BIOLOGY, 2015, 427 (02) : 221 - 224
  • [8] Discrimination of soluble and aggregation-prone proteins based on sequence information
    Fang, Yaping
    Fang, Jianwen
    MOLECULAR BIOSYSTEMS, 2013, 9 (04) : 806 - 811
  • [9] The Aggregation-Prone Mutant Huntingtin Protein in a Cellular Context - Approaches by Super-Resolution Imaging
    Sahl, Steffen J.
    Vonk, Willianne I. M.
    Weiss, Lucien E.
    Lau, Lana
    Frydman, Judith
    Moerner, W. E.
    BIOPHYSICAL JOURNAL, 2014, 106 (02) : 683A - 683A
  • [10] SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of Huntingtin
    Ohkuni, Kentaro
    Pasupala, Nagesh
    Peek, Jennifer
    Holloway, Grace Lauren
    Sclar, Gloria D.
    Levy-Myers, Reuben
    Baker, Richard E.
    Basrai, Munira A.
    Kerscher, Oliver
    FRONTIERS IN GENETICS, 2018, 9
12345