Current characteristics of hemophilia patients co-infected with HIV/HCV in Japan

被引：12

作者：

Miuma, Satoshi ^{[1
]}

Hidaka, Masaaki ^{[2
]}

Takatsuki, Mitsuhisa ^{[2
]}

Natsuda, Koji ^{[2
]}

Soyama, Akihiko ^{[2
]}

Miyaaki, Hisamitsu ^{[1
]}

Kanda, Yasuko ^{[1
]}

Tamada, Yoko ^{[1
]}

Shibata, Hidetaka ^{[1
]}

Ozawa, Eisuke ^{[1
]}

Taura, Naota ^{[1
]}

Eguchi, Susumu ^{[2
]}

Nakao, Kazuhiko ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Sakamoto 1-7-1, Nagasaki, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg, Nagasaki, Nagasaki 8528501, Japan

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2018年 / 15卷 / 02期

关键词：

human immunodeficiency virus; hepatitis C virus; hemophilia; genotype; liver cirrhosis; HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONIC HEPATITIS-C; LIVER FIBROSIS; MORTALITY; COINFECTION; MORBIDITY; BURDEN; HIV;

D O I：

10.3892/etm.2017.5603

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Over 30 years have passed since co-infection with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) was first documented in hemophilia patients in Japan. In such cases, the leading cause of mortality is reportedly HCV-associated end-stage liver disease. However, the current characteristics of hemophilia patients co-infected with HIV/HCV are unknown. The aim of the present study was to reveal the current characteristics, notably HCV geno-prevalence and liver function, among hemophilia patients co-infected with HIV/HCV in Japan. Current characteristics were evaluated using cross-sectional retrospective data of 44 hemophilia patients positive for anti-HCV and anti-HIV antibodies who underwent screening of liver dysfunction. A total of 56.8% of hemophilia patients co-infected with HIV/HCV were positive for HCV RNA. The most common HCV genotypes were 1a, 1b and 3a. Liver cirrhosis was diagnosed in 26.3% patients negative for HCV RNA and 60.0% patients positive for HCV RNA. Decompensated liver cirrhosis was diagnosed in 33.3% HCV RNA-positive patients and none of the HCV RNA-negative patients. The rate of liver cirrhosis was greater for HCV genotype 3a compared with other genotypes. Overall, the current primary HCV RNA genotypes among hemophilia patients co-infected with HIV/HCV are 1a, 1b and 3a. Over 50% of HIV/HCV co-infected hemophilia patients positive for HCV RNA were diagnosed with liver cirrhosis and some were diagnosed with decompensated liver cirrhosis.

引用

页码：2148 / 2155

页数：8

共 19 条

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