Cellular antioxidant activity and in vitro inhibition of α-glucosidase, α-amylase and pancreatic lipase of oregano polyphenols under simulated gastrointestinal digestion

被引：104

作者：

Gutierrez-Grijalva, Erick P. ^{[1
]}

Antunes-Ricardo, Marilena ^{[2
]}

Acosta-Estrada, Beatriz A. ^{[2
]}

Gutierrez-Uribe, Janet A. ^{[3
]}

Basilio Heredia, J. ^{[1
]}

机构：

[1] CONACYT Ctr Invest Alimentac & Desarrollo AC, Carretera ElDorado Km 5-5, Culiacan 80110, Sinaloa, Mexico

[2] Tecnol Monterrey, Escuela Ingn & Ciencias, Ctr Biotecnol FEMSA, Av Eugenio Garza Sada 2501 Sur, Monterrey 64849, NL, Mexico

[3] Tecnol Monterrey, Escuela Ingn & Ciencias, Campus Puebla,Via Atlicayotl 2301, Puebla 72453, Pue, Mexico

来源：

FOOD RESEARCH INTERNATIONAL | 2019年 / 116卷

关键词：

Lippia graveolens; Lippia palmeri; Hedeoma patens; Bioavailability; Polyphenols; Gastrointestinal digestion; METABOLIC SYNDROME; PHENOLIC-COMPOUNDS; LIPPIA-GRAVEOLENS; IDENTIFICATION; EXTRACTS; FRUITS; ASSAY; BIOACCESSIBILITY; HYPERTENSION; STABILITY;

D O I：

10.1016/j.foodres.2018.08.096

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Different oregano species have been traditionally used as infusions in folk medicine. Oregano medicinal properties, such as antioxidant and anti-inflammatory, have been partially attributed to its polyphenolic content. However, information regarding bioaccessibility of oregano polyphenols is limited. Cell-based antioxidant activity, and in vitro hypoglycemic, and hypolipidemic properties of polyphenolic extracts from three species of oregano species, namely, Hedeoma patens (HP), Lippia graveolens (LG) and Lippia palmeri (LP), subjected to simulated gastrointestinal digestion were evaluated. LC-TOF-MS analysis of HP, LG and LP allowed the identification of 9 flavonoids and 6 hydroxycinnamic acid derivatives with nutraceutical significance. Oregano polyphenolic extracts and digests from HP, LG, and LP exhibited cellular antioxidant capacity, hypoglycemic and hypolipidemic properties. Altogether, our results suggest that HP, LG and LP polyphenols exhibit potential for use as hypoglycemic, hypolipidemic, and antioxidant agents.

引用

页码：676 / 686

页数：11

共 63 条

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