Progression-free survival as surrogate endpoint of overall survival in esophageal squamous cell carcinoma: a real-world data and literature-based analysis

被引：2

作者：

Han, Weiming ^{[1
]}

Wang, Lan ^{[2
]}

Li, Chen ^{[3
]}

Chen, Junqiang ^{[4
]}

Zhang, Wencheng ^{[3
]}

Wang, Xin ^{[1
]}

Pang, Qingsong ^{[3
]}

Zhao, Yidian ^{[5
]}

Sun, Xinchen ^{[6
]}

Zhang, Kaixian ^{[7
]}

Li, Gaofeng ^{[8
]}

Li, Ling ^{[7
]}

Qiao, Xueying ^{[2
]}

Liu, Miaoling ^{[9
]}

Wang, Yadi ^{[10
]}

Deng, Lei ^{[1
]}

Wang, Wenqing ^{[1
]}

Bi, Nan ^{[1
]}

Zhang, Tao ^{[1
]}

Deng, Wei ^{[11
,12
]}

Ni, Wenjie ^{[13
]}

Chang, Xiao ^{[1
]}

Zhou, Zongmei ^{[1
]}

Liang, Jun ^{[14
]}

Feng, Qinfu ^{[1
]}

Wang, Lvhua ^{[14
]}

Chen, Dongfu ^{[1
]}

Lv, Jima ^{[1
]}

Zhu, Shuchai ^{[2
]}

Han, Chun ^{[2
]}

Xiao, Zefen ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Radiat Oncol, Natl Clin Res Ctr Canc,Canc Hosp, 17 Panjiayuan South Lane, Beijing 100021, Peoples R China

[2] Hebei Med Univ, Dept Radiat Oncol, Hosp 4, 12 Hlth Rd, Shijiazhuang, Hebei, Peoples R China

[3] Tianjin Med Univ, Dept Radiat Oncol, Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjin, Peoples R China

[4] Fujian Med Univ, Dept Radiat Oncol, Fujian Canc Hosp, Canc Hosp, Fuzhou, Peoples R China

[5] Anyang Canc Hosp, Dept Radiat Oncol, Anyang, Peoples R China

[6] Nanjing Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Nanjing, Peoples R China

[7] Tengzhou Cent Peoples Hosp, Dept Oncol, Tengzhou, Peoples R China

[8] Beijing Hosp, Natl Ctr Gerontol, Dept Radiat Oncol, Beijing, Peoples R China

[9] Hebei Univ, Dept Radiat Oncol, Affiliated Hosp, Baoding, Peoples R China

[10] PLA Army Gen Hosp, Dept Radiat Oncol, Beijing, Peoples R China

[11] Peking Univ, Beijing Canc Hosp, Dept Radiat Oncol, Sch Oncol, Beijing, Peoples R China

[12] Beijing Inst Canc Res, Beijing, Peoples R China

[13] Capital Med Univ, Peking Univ, Sch Clin Med 9, Beijing Shijitan Hosp,Dept Radiat Oncol,Sch Oncol, Beijing, Peoples R China

[14] Chinese Acad Med Sci, Shenzhen Hosp, Dept Radiat Oncol, Canc Hosp, Shenzhen, Peoples R China

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2022年 / 14卷

关键词：

esophageal cancer; overall survival; progression-free survival; radiotherapy; surrogate endpoint; SALVAGE ESOPHAGECTOMY; DEFINITIVE CHEMORADIOTHERAPY; RADIOTHERAPY; CANCER; CHEMORADIATION; CHEMOTHERAPY; OUTCOMES;

D O I：

10.1177/17588359221131526

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The surrogacy of progression-free survival (PFS) for overall survival (OS) in esophageal squamous cell carcinoma (ESCC) remains unelucidated. This study aimed to determine the validity of PFS as a surrogate endpoint for OS in ESCC patients treated with definitive radiotherapy or definitive chemoradiotherapy (dRT/dCRT), as well as characterize the prognostic factors and survival of such patients. Methods: A total of 3662 patients from 10 cancer centers were enrolled. One-, 2-, and 3-year PFS (PFS12, PFS24, and PSF36, respectively) were used as time points for analysis. At each time point, ESCC-specific mortality and OS were characterized using competing risk and conditional survival models, while correlation between PFS and OS was evaluated by linear regression. Results: At PFS12, PFS24, and PFS36, a progressive decrease in 5-year ESCC-specific mortality (35.2%-13.4%) and increase in 5-year OS (46.6%-62.9%) were observed. Regardless, the OS of patients remained markedly lower than those of the age- and sex-matched Chinese general population. TNM stage remained a significant prognostic factor at PFS36. Strong correlation was found between 3-year PFS and 5-year OS, which was further externally validated. Conclusions: Three-year PFS may act as a potential surrogate endpoint for 5-year OS. TNM stage was considered a significant prognostic factor for OS, and may represent the optimal prognostic tool to guide clinical decision-making and post-treatment follow-up.

引用

页数：11

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