A candidate gene approach to searching for low-penetrance breast and prostate cancer genes

被引：143

作者：

Hunter, DJ ^{[1
]}

Riboli, E ^{[1
]}

Haiman, CA ^{[1
]}

Albanes, D ^{[1
]}

Altshuler, D ^{[1
]}

Chanock, SJ ^{[1
]}

Hayes, RB ^{[1
]}

Henderson, BE ^{[1
]}

Kaaks, R ^{[1
]}

Stram, DO ^{[1
]}

Thomas, G ^{[1
]}

Thun, MJ ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 12期

关键词：

D O I：

10.1038/nrc1754

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium - a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer - was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers - the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway - and to associate these variations with cancer risk.

引用

页码：977 / 985

页数：9

共 50 条

[31] Common low-penetrance risk variants associated with breast cancer in Polish women
Joanna K Ledwoń
Ewa E Hennig
Natalia Maryan
Krzysztof Goryca
Dorota Nowakowska
Anna Niwińska
Jerzy Ostrowski
BMC Cancer, 13
[32] Common low-penetrance risk variants associated with breast cancer in Polish women
Ledwon, Joanna K.
Hennig, Ewa E.
Maryan, Natalia
Goryca, Krzysztof
Nowakowska, Dorota
Niwinska, Anna
Ostrowski, Jerzy
BMC CANCER, 2013, 13
[33] Quantifying the cumulative effect of low-penetrance genetic variants on breast cancer risk
Smyth, Conor
Spakulova, Iva
Cotton-Barratt, Owen
Rafiq, Sajjad
Tapper, William
Upstill-Goddard, Rosanna
Hopper, John L.
Makalic, Enes
Schmidt, Daniel F.
Kapuscinski, Miroslav
Fliege, Joerg
Collins, Andrew
Brodzki, Jacek
Eccles, Diana M.
MacArthur, Ben D.
MOLECULAR GENETICS & GENOMIC MEDICINE, 2015, 3 (03): : 182 - 188
[34] A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements
Ellsworth, Darrell L.
Turner, Clesson E.
Ellsworth, Rachel E.
JOURNAL OF ONCOLOGY, 2019, 2019
[35] Novel approaches to identify low-penetrance cancer susceptibility genes using mouse models
de Koning, JP
Mao, JH
Balmain, A
TUMOR PREVENTION AND GENETICS, 2003, 163 : 19 - 27
[36] Low-Penetrance Susceptibility Variants in Familial Colorectal Cancer
Niittymaki, Iina
Kaasinen, Eevi
Tuupanen, Sari
Karhu, Auli
Jarvinen, Heikki
Mecklin, Jukka-Pekka
Tomlinson, Ian P. M.
Di Bernardo, Maria Chiara
Houlston, Richard S.
Aaltonen, Lauri A.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2010, 19 (06) : 1478 - 1483
[37] High- and low-penetrance cutaneous melanoma susceptibility genes
Fargnoli, Maria Concetta
Argenziano, Giuseppe
Zalaudek, Iris
Peris, Ketty
EXPERT REVIEW OF ANTICANCER THERAPY, 2006, 6 (05) : 657 - 670
[38] The breast cancer low-penetrance allele 1100delC in the CHEK2 gene is not present in Spanish familial breast cancer population
Osorio, A
Rodríguez-López, R
Díez, O
de la Hoya, M
Martínez, JI
Vega, A
Esteban-Cardeñosa, E
Alonso, C
Caldés, T
Benítez, J
INTERNATIONAL JOURNAL OF CANCER, 2004, 108 (01) : 54 - 56
[39] Low-penetrance variants underlying familial colorectal cancer
Niittymaki, Lina
Kaasinen, Eevi
Karhu, Auli
Jarvinen, Heikki
Mecklin, Jukka-Pekka
Tomlinson, Ian Pm
Houlston, Richard S.
Aaltonen, Lauri A.
CANCER RESEARCH, 2010, 70
[40] Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: Not present in the Chinese familial breast cancer population
Wang Chen
Shi Yurong
Ning Liansheng
Advances in Therapy, 2008, 25 : 496 - 501

← 1 2 3 4 5 →