A candidate gene approach to searching for low-penetrance breast and prostate cancer genes

被引：143
作者：
Hunter, DJ [1 ]
Riboli, E [1 ]
Haiman, CA [1 ]
Albanes, D [1 ]
Altshuler, D [1 ]
Chanock, SJ [1 ]
Hayes, RB [1 ]
Henderson, BE [1 ]
Kaaks, R [1 ]
Stram, DO [1 ]
Thomas, G [1 ]
Thun, MJ [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA
来源：
NATURE REVIEWS CANCER | 2005年 / 5卷 / 12期
关键词：
D O I：
10.1038/nrc1754
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium - a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer - was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers - the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway - and to associate these variations with cancer risk.
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收藏
页码：977 / 985
页数：9
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