Bacterial magnetic nanoparticles as drug carriers

被引：29

作者：

Guo, Lin ^{[1
,2
]}

Huang, Ji ^{[3
]}

Zhang, Xin ^{[1
,2
]}

Li, Ying ^{[4
,5
]}

Zheng, Limin ^{[3
]}

机构：

[1] Nanjing Univ, Key Lab Mesoscop Chem MOE, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China

[3] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

[4] China Agr Univ, State Key Labs Agrobiotechnol, Beijing 100193, Peoples R China

[5] China Agr Univ, Coll Biol Sci, Beijing 100193, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2008年 / 18卷 / 48期

关键词：

D O I：

10.1039/b808556k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Magnet doxorubicin (DOX) drugs are efficiently produced by using bacterial magnetic nanoparticles (BMP) as anti-cancer drug carriers and dual functional cross-linkers glutaraldehyde, disuccinimidyl (DSS), N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and di(N-succinimidyl) carbonate (DSC) as coupling reagents. Glutaraldehyde shows the highest coupling efficiency with the DOX load ratio of about 46.6%. Doxorubicin coupled bacterial magnetic nanoparticles (DBMP) disperse well in aqueous solution, exhibit a narrow size distribution with mean diameter about 70 nm and a high magnetic response with ferromagnetic properties, and show strong cytotoxicity to HePG2 and MCF-7 cancer cells.

引用

页码：5993 / 5997

页数：5

共 27 条

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