Bacterial magnetic nanoparticles as drug carriers

被引：29
作者：
Guo, Lin [1 ,2 ]
Huang, Ji [3 ]
Zhang, Xin [1 ,2 ]
Li, Ying [4 ,5 ]
Zheng, Limin [3 ]
机构：
[1] Nanjing Univ, Key Lab Mesoscop Chem MOE, Nanjing 210093, Peoples R China
[2] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China
[3] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China
[4] China Agr Univ, State Key Labs Agrobiotechnol, Beijing 100193, Peoples R China
[5] China Agr Univ, Coll Biol Sci, Beijing 100193, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY | 2008年 / 18卷 / 48期
关键词：
D O I：
10.1039/b808556k
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Magnet doxorubicin (DOX) drugs are efficiently produced by using bacterial magnetic nanoparticles (BMP) as anti-cancer drug carriers and dual functional cross-linkers glutaraldehyde, disuccinimidyl (DSS), N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and di(N-succinimidyl) carbonate (DSC) as coupling reagents. Glutaraldehyde shows the highest coupling efficiency with the DOX load ratio of about 46.6%. Doxorubicin coupled bacterial magnetic nanoparticles (DBMP) disperse well in aqueous solution, exhibit a narrow size distribution with mean diameter about 70 nm and a high magnetic response with ferromagnetic properties, and show strong cytotoxicity to HePG2 and MCF-7 cancer cells.
引用
收藏
页码：5993 / 5997
页数：5
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