Hydroxycut hepatotoxicity: A case series and review of liver toxicity from herbal weight loss supplements

被引:87
作者
Dara, Lily [2 ]
Hewett, Jennifer
Lim, Joseph Kartaik [1 ]
机构
[1] Yale Univ, Sch Med, Sect Digest Dis, Yale Viral Hepatitis Program,Yale Liver Ctr, New Haven, CT 06520 USA
[2] Griffin Hosp, Dept Med, Derby, CT 06520 USA
关键词
Hydroxycut; Dietary supplements; Liver; Liver failure; Toxicity; Weight loss; Medicine; Hepatitis;
D O I
10.3748/wjg.14.6999
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Dietary supplements represent an increasingly common source of drug-induced liver injury. Hydroxycut is a popular weight loss supplement which has previously been linked to hepatotoxicity, although the individual chemical components underlying liver injury remain poorly understood. We report two cases of acute hepatitis in the setting of Hydroxycut exposure and describe possible mechanisms of liver injury. We also comprehensively review and-summarize the existing literature on commonly used weight loss supplements, and their individual components which have demonstrated potential for liver toxicity. An increased effort to screen for and educate patients and physicians about supplement-associated hepatotoxicity is warranted. (C) 2008 The WJG Press. All rights reserved.
引用
收藏
页码:6999 / 7004
页数:6
相关论文
共 71 条
[1]  
Abu el Wafa Y, 2005, An Med Interna, V22, P298
[2]   Fatal liver failure following food supplements during chronic treatment with montelukast [J].
Actis, G. C. ;
Bulgianesi, E. ;
Ottobrelli, A. ;
Rizzetto, M. .
DIGESTIVE AND LIVER DISEASE, 2007, 39 (10) :953-955
[3]   Pennyroyal toxicity: Measurement of toxic metabolite levels in two cases and review of the literature [J].
Anderson, IB ;
Mullen, WH ;
Meeker, JE ;
KhojastehBakht, SC ;
Oishi, S ;
Nelson, SD ;
Blanc, PD .
ANNALS OF INTERNAL MEDICINE, 1996, 124 (08) :726-+
[4]   ESSENTIALITY OF CHROMIUM IN HUMANS [J].
ANDERSON, RA .
SCIENCE OF THE TOTAL ENVIRONMENT, 1989, 86 (1-2) :75-81
[5]  
Anderson RA, 1998, NUTR REV, V56, P266, DOI 10.1111/j.1753-4887.1998.tb01763.x
[6]   STUDIES ON MEDICINAL-PLANTS OF SRI-LANKA .14. TOXICITY OF SOME TRADITIONAL MEDICINAL HERBS [J].
ARSECULERATNE, SN ;
GUNATILAKA, AAL ;
PANABOKKE, RG .
JOURNAL OF ETHNOPHARMACOLOGY, 1985, 13 (03) :323-335
[7]  
Bakerink JA, 1996, PEDIATRICS, V98, P944
[8]   Acute hepatitis induced by greater celandine (Chelidonium majus) [J].
Benninger, J ;
Schneider, HT ;
Schuppan, D ;
Kirchner, T ;
Hahn, EG .
GASTROENTEROLOGY, 1999, 117 (05) :1234-1237
[9]  
Biegert C, 2004, J RHEUMATOL, V31, P2121
[10]   Use of nonprescription weight loss products - Results from a multistate survey [J].
Blanck, HM ;
Khan, LK ;
Serdula, MK .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (08) :930-935