Palladium-Catalyzed Benzylation of Carboxylic Acids with Toluene via Benzylic C-H Activation

被引：97

作者：

Liu, Hongqiang ^{[1
]}

Shi, Guangfa ^{[1
]}

Pan, Shulei ^{[1
]}

Jiang, Yuyu ^{[1
]}

Zhang, Yanghui ^{[1
]}

机构：

[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 16期

关键词：

BOND FORMATION; CARBON-HYDROGEN; OXIDATIVE FUNCTIONALIZATION; COUPLING REACTIONS; ACETOXYLATION; ESTERIFICATION; ALKYLBENZENES; LACTONIZATION; PHI(OAC)(2); COMPLEXES;

D O I：

10.1021/ol401687f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct benzylation of carboxylic acids with toluene has been developed via palladium-catalyzed C-H acyloxylation under 1 atm of oxygen. This reaction demonstrates good functional group tolerance and high yields, providing a facile, atom-economic, and efficient method for the synthesis of benzyl esters.

引用

页码：4098 / 4101

页数：4

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