Enantioselective total synthesis of batzelladine A

被引：60

作者：

Shimokawa, J ^{[1
]}

Shirai, K ^{[1
]}

Tanatani, A ^{[1
]}

Hashimoto, Y ^{[1
]}

Nagasawa, K ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 12期

关键词：

alkaloids; cycloaddition; natural products; oxidation; total synthesis;

D O I：

10.1002/anie.200353200

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One-step formation of an enone from a primary alcohol has been effectively applied in the total synthesis of batzelladine A (1). Successive 1,3-dipolar cycloadditions with a subsequent cyclization were used to form the tricyclic guanidine subunit of this natural product, which has the strongest inhibitory activity of HIV gp120-CD4 binding among the batzelladines.

引用

页码：1559 / 1562

页数：4

共 35 条

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