Hypoxia-related molecules HIF-1α, CA9, and osteopontin Predictors of survival in patients with high-grade glioma

被引：32
作者：
Erpolat, O. P. [1 ]
Gocun, P. U. [2 ]
Akmansu, M. [1 ]
Ozgun, G. [2 ]
Akyol, G. [2 ]
机构：
[1] Gazi Univ, Dept Radiat Oncol, Sch Med, Ankara, Turkey
[2] Gazi Univ, Sch Med, Dept Pathol, Ankara, Turkey
来源：
STRAHLENTHERAPIE UND ONKOLOGIE | 2013年 / 189卷 / 02期
关键词：
High-grade glioma; Hypoxia; Osteopontin; Survival; Prognostic factors; INDUCIBLE FACTOR-1; TUMOR HYPOXIA; EXPRESSION; ANGIOGENESIS; GLIOBLASTOMA; BRAIN; OVEREXPRESSION; IDENTIFICATION; BIOMARKERS; PROGNOSIS;
D O I：
10.1007/s00066-012-0262-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A high expression of hypoxia-inducible factor-1 alpha (HIF)-1 alpha, carbonic anhydrase 9 (CA9), aontin appears to be a strong prognostic indicator in many malignancies; however, their role is unclear in high-grade gliomas. HIF-1 alpha, CA9, and osteopontin levels in tissue specimens of 92 patients with high-grade glioma were evaluated by immunohistochemistry. Patients with a high expression of cytoplasmic and nuclear HIF-1 alpha, CA9, and osteopontin had significantly shorter overall survival. The expression results of these markers were combined to form a hypoxic profile, and high hypoxic scores (expression of two or three markers) were significantly correlated to poorer overall survival. In multivariate analysis, high hypoxic score-1 (cytoplasmic HIF-1 alpha, CA9, and osteopontin) was the only independent negative prognostic factor for survival (p = 0.028). Our results showed that a combination of hypoxic markers is more robust than a single marker for predicting survival in high-grade glioma. It may be necessary to utilize the hypoxic score in selecting patients for targeted therapy in the future.
引用
收藏
页码：147 / 154
页数：8
相关论文
共 32 条
[1]   Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma [J].
Atai, Nadia A. ;
Bansal, Manju ;
Lo, Cheungh ;
Bosman, Joost ;
Tigchelaar, Wikky ;
Bosch, Klazien S. ;
Jonker, Ard ;
Hamer, Philip C. De Witt ;
Troost, Dirk ;
McCulloch, Christopher A. ;
Everts, Vincent ;
Van Noorden, Cornelis J. F. ;
Sodek, Jaro .
IMMUNOLOGY, 2011, 132 (01) :39-48
[2]  
Birner P, 2000, CANCER RES, V60, P4693
[3]   Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma [J].
Bos, R ;
van der Groep, P ;
Greijer, AE ;
Shvarts, A ;
Meijer, S ;
Pinedo, HM ;
Semenza, GL ;
van Diest, PJ ;
van der Wall, E .
CANCER, 2003, 97 (06) :1573-1581
[4]   Prognostic Impact of Hemoglobin Level and Other Factors in Patients with High-Grade Gliomas Treated with Postoperative Radiochemotherapy and Sequential Chemotherapy Based on Temozolomide A 10-Year Experience at a Single Institution [J].
Cefaro, Giampiero Ausili ;
Genovesi, Domenico ;
Vinciguerra, Annamaria ;
Trignani, Marianna ;
Taraborrelli, Maria ;
Augurio, Antonietta ;
Buonaguidi, Roberto ;
Galzio, Renato J. ;
Di Nicola, Marta .
STRAHLENTHERAPIE UND ONKOLOGIE, 2011, 187 (12) :778-783
[5]   Identification of genes differentially expressed in glioblastoma versus pilocytic astrocytoma using Suppression Subtractive Hybridization [J].
Colin, C ;
Baeza, N ;
Bartoli, C ;
Fina, F ;
Eudes, N ;
Nanni, I ;
Martin, PM ;
Ouafik, L ;
Figarella-Branger, D .
ONCOGENE, 2006, 25 (19) :2818-2826
[6]   Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies [J].
Coppola, D ;
Szabo, M ;
Boulware, D ;
Muraca, P ;
Alsarraj, M ;
Chambers, AF ;
Yeatman, TJ .
CLINICAL CANCER RESEARCH, 2004, 10 (01) :184-190
[7]  
Ding Q, 2002, CANCER RES, V62, P5336
[8]   Biological consequences of tumor hypoxia [J].
Höckel, M ;
Vaupel, P .
SEMINARS IN ONCOLOGY, 2001, 28 (02) :36-41
[9]  
Hui EP, 2002, CLIN CANCER RES, V8, P2595
[10]   Protocol of radiotherapy for glioblastoma according to the expression of HIF-1 [J].
Irie N. ;
Matsuo T. ;
Nagata I. .
Brain Tumor Pathology, 2004, 21 (1) :1-6
1234