Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China

被引：21
作者：
Castro, Felipe A. [1 ]
Koshiol, Jill [1 ]
Hsing, Ann W. [1 ]
Gao, Yu-Tang [2 ]
Rashid, Asif [3 ]
Chu, Lisa W. [1 ]
Shen, Ming-Chang [4 ]
Wang, Bing-Shen [5 ]
Han, Tian-Qua [6 ]
Zhang, Bai-He [7 ]
Niwa, Shelley [8 ]
Yu, Kai [1 ]
Zhang, Hong [9 ]
Chanock, Stephen [1 ,10 ]
Andreotti, Gabriella [1 ]
机构：
[1] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20892 USA
[2] Shanghai Canc Inst, Shanghai, Peoples R China
[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
[4] Shanghai Tumor Hosp, Shanghai, Peoples R China
[5] Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China
[6] Shanghai Med Univ 2, Ruijin Hosp, Dept Surg, Shanghai, Peoples R China
[7] Second Mil Med Univ, Inst Oriental Hepatobiliary Surg, Shanghai, Peoples R China
[8] WESTAT Corp, Rockville, MD 20850 USA
[9] Fudan Univ, Sch Life Sci, Inst Biostat, Shanghai 200433, Peoples R China
[10] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Adv Technol Ctr, Bethesda, MD 20892 USA
来源：
BMC CANCER | 2012年 / 12卷
关键词：
Biliary tract cancer; Biliary stones; Inflammation; Genetic susceptibility; GALLBLADDER CANCER; POLYMORPHISMS; INFECTION; SHANGHAI; GALLSTONES; SYSTEM;
D O I：
10.1186/1471-2407-12-468
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies. Methods: To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes related to inflammation (IL8, NFKBIL, RNASEL, TNF, and VEGFA) in 456 participants with incident biliary tract cancer cases (262 gallbladder, 141 extrahepatic bile duct, 53 ampulla of Vater), 982 participants with biliary stones, and 860 healthy controls in a population-based case-control study in Shanghai, China. Results: Suggestive associations were observed for SNPs in VEGFA with biliary stones, IL8 with gallbladder and ampulla of Vater cancers, and RNASEL with ampulla of Vater cancer (false discovery rate <= 0.2). Conclusion: These findings provide additional support for the role of inflammation in biliary stones and biliary tract cancer risk and need further validation.
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页数：6
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