Prevalence and pattern of brown adipose tissue distribution of 18F-FDG in patients undergoing PET-CT in a subtropical climatic zone

被引:37
作者
Perkins, Alan C. [1 ,2 ]
Mshelia, Dahiru S. [4 ]
Symonds, Michael E. [3 ]
Sathekge, Mike [4 ]
机构
[1] Univ Nottingham, Queens Med Ctr, Div Radiol & Imaging Sci, Sch Clin Sci, Nottingham NG7 2UH, England
[2] Univ Nottingham, Queens Med Ctr, Nottingham Digest Dis Biomed Res Unit, Nottingham NG7 2UH, England
[3] Univ Nottingham, Queens Med Ctr, Early Life Nutr Res Unit, Acad Div,Child Hlth & Resp Biomed Res Unit, Nottingham NG7 2UH, England
[4] Steve Biko Acad Hosp, Dept Nucl Med, Pretoria, South Africa
关键词
brown adipose tissue; brown fat; F-18-FDG imaging; PET imaging; subtropical climate; FAT; OBESITY;
D O I
10.1097/MNM.0b013e32835bbbf0
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background The uptake of F-18-FDG in brown adipose tissue (BAT) may have important implications in understanding the pathophysiology of BAT and obesity. Because of the thermal implications of BAT uptake of F-18-FDG, this study aimed to contribute to existing knowledge by assessing patients scanned in a subtropical environment with particular reference to ethnicity. Patients and methods A retrospective study was carried out to determine the prevalence and pattern of BAT uptake in patients undergoing F-18-FDG PET-CT imaging in a PET facility located in a subtropical climatic zone. Standardized uptake values were obtained for regions of BAT uptake of F-18-FDG, and the distribution pattern was assessed according to anatomical region, sex, age, BMI and ethnicity. Results Following a reveiw of a total of 386 scans, 38 patients showed BAT uptake of F-18-FDG (9.85%), with the mass and activity of BAT being greater in women than in men (11.95 and 6.88%, respectively). BAT uptake of F-18-FDG in the neck/supraclavicular, axillary and mediastinal regions was greater in adults whose BMI was less than (18) kg/m(2). However, perirenal BAT activity was shown to be greater in obese individuals. The frequency of BAT uptake of F-18-FDG was 55% in winter as against 45% during summer (P<0.012). There was no statistical difference in BAT uptake between black and white patients. Conclusion This study shows the pattern and prevalence of BAT in patients in a subtropical environment. Although the average seasonal temperatures are higher in a subtropical climate, a seasonal variation in BAT expression was observed, although there were no differences with respect to patient ethnicity. Nucl Med Commun 34:168-174 (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:168 / 174
页数:7
相关论文
共 50 条
  • [21] The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by 18F-FDG PET/CT in a patient with adrenal pheochromocytoma
    Lilian Yuri Itaya Yamaga
    Anneliese Fischer Thom
    Jairo Wagner
    Ronaldo Hueb Baroni
    Jairo Tabacow Hidal
    Marcelo Gusmão Funari
    European Journal of Nuclear Medicine and Molecular Imaging, 2008, 35 : 446 - 447
  • [22] The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by 18F-FDG PET/CT in a patient with adrenal pheochromocytoma
    Itaya Yamaga, Lilian Yuri
    Thom, Anneliese Fischer
    Wagner, Jairo
    Baroni, Ronaldo Hueb
    Hidal, Jairo Tabacow
    Funari, Marcelo Gusmao
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (02) : 446 - 447
  • [23] 18F-FDG PET/CT Monitoring of β3 Agonist-Stimulated Brown Adipocyte Recruitment in White Adipose Tissue
    Park, Jin Won
    Jung, Kyung-Ho
    Lee, Jin Hee
    Cung Hoa Thien Quach
    Moon, Seung-Hwan
    Cho, Young Seok
    Lee, Kyung-Han
    JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (01) : 153 - 158
  • [24] Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyses
    Martinez-Tellez, Borja
    Sanchez-Delgado, Guillermo
    Boon, Mariette R.
    Rensen, Patrick C. N.
    Llamas-Elvira, Jose M.
    Ruiz, Jonatan R.
    MOLECULAR IMAGING AND BIOLOGY, 2020, 22 (02) : 425 - 433
  • [25] Unilateral Reduction of 18F-FDG Accumulation in Brown Adipose Tissue by Sympathectomy for Hyperhidrosis
    Shirakawa, Chigusa
    Koyasu, Sho
    Takada, Masahiro
    Toi, Masakazu
    Nakamoto, Yuji
    CLINICAL NUCLEAR MEDICINE, 2023, 48 (01) : 79 - 80
  • [26] Melatonin deficiency decreases brown adipose tissue acute thermogenic capacity of in rats measured by 18F-FDG PET
    Bruno Halpern
    Marcio C. Mancini
    Caroline Mendes
    Camila Maria Longo Machado
    Silvana Prando
    Marcelo Tatit Sapienza
    Carlos Alberto Buchpiguel
    Fernanda Gaspar do Amaral
    José Cipolla-Neto
    Diabetology & Metabolic Syndrome, 12
  • [27] Melatonin deficiency decreases brown adipose tissue acute thermogenic capacity of in rats measured by 18F-FDG PET
    Halpern, Bruno
    Mancini, Marcio C.
    Mendes, Caroline
    Machado, Camila Maria Longo
    Prando, Silvana
    Sapienza, Marcelo Tatit
    Buchpiguel, Carlos Alberto
    do Amaral, Fernanda Gaspar
    Cipolla-Neto, Jose
    DIABETOLOGY & METABOLIC SYNDROME, 2020, 12 (01)
  • [28] Brown Adipose Tissue at F-18 FDG PET/CT: Correlation of Metabolic Parameter with Demographics and Cancer-Related Characteristics in Cancer Patients
    Bakhshayeshkaram, Mehrdad
    Aghahosseini, Farahnaz
    Dehghani, Zahra
    Doroudinia, Abtin
    Hassanzad, Maryam
    Ansari, Mojtaba
    Jamaati, Hamid Reza
    IRANIAN JOURNAL OF RADIOLOGY, 2018, 15 (03)
  • [29] Brown Adipose Tissue in Breast Cancer Evaluated by [18F] FDG-PET/CT
    Leonardo Pace
    Emanuele Nicolai
    Luca Basso
    Nunzia Garbino
    Andrea Soricelli
    Marco Salvatore
    Molecular Imaging and Biology, 2020, 22 : 1111 - 1115
  • [30] Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue
    Baba, Shingo
    Tatsumi, Mitsuaki
    Ishimori, Takayoshi
    Lilien, David L.
    Engles, James M.
    Wahl, Richard L.
    JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (06) : 981 - 986