Doxycycline as a potential partner of COVID-19 therapies

被引：68

作者：

Malek, Alexandre E. ^{[1
]}

Granwehr, Bruno P. ^{[1
]}

Kontoyiannis, Dimitrios P. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, 1515 Holcombe Blvd, Houston, TX 77030 USA

来源：

IDCASES | 2020年 / 21卷

关键词：

COVID-19; Hydroxychloroquine; Doxycycline; 2019 novel coronavirus; Remdesivir; VIRAL MESSENGER-RNAS; ACUTE LUNG INJURY; MATRIX METALLOPROTEINASES; CORONAVIRUS; REPLICATION; PNEUMONIA; TARGETS; DENGUE;

D O I：

10.1016/j.idcr.2020.e00864

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Coronavirus disease 2019 (COVID-19) is a major public health challenge, and the current antiviral arsenal for treatment is limited, with questionable efficacy. Major efforts are under way for discovery of new effective agents, but the validation of new potential treatments for COVID-19 may take a long time. Therefore, the repurposing of existing drugs for new indications is needed. In this article, we argue for the potential benefits of using doxycycline with either hydroxycholoroquine or other putative agents for COVID-19 treatment, as doxycycline has antiviral and anti-inflammatory activities by dampening the cytokine storm and to prevent lung damage. (C) 2020 The Authors. Published by Elsevier Ltd.

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