Serum Trace Elements and Their Associations with Breast Cancer Subgroups in Korean Breast Cancer Patients

被引：44

作者：

Choi, Rihwa ^{[1
,2
]}

Kim, Min-Ji ^{[3
]}

Sohn, Insuk ^{[3
]}

Kim, Serim ^{[2
]}

Kim, Isaac ^{[4
]}

Ryu, Jai Min ^{[4
]}

Choi, Hee Jun ^{[4
]}

Kim, Jae-Myung ^{[4
]}

Lee, Se Kyung ^{[4
]}

Yu, Jonghan ^{[4
]}

Kim, Seok Won ^{[4
]}

Nam, Seok Jin ^{[4
]}

Lee, Jeong Eon ^{[4
]}

Lee, Soo-Youn ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, 81 Irwon Ro, Seoul 06351, South Korea

[2] Green Cross Labs, Dept Lab Med, Yongin 16924, Gyeonggi, South Korea

[3] Samsung Med Ctr, Res Inst Future Med, Stat & Data Ctr, Seoul 06351, South Korea

[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Breast Div,Dept Surg, 81 Irwon Ro, Seoul 06351, South Korea

来源：

NUTRIENTS | 2019年 / 11卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

breast cancer; trace elements; molybdenum; manganese; FEMALE-PATIENTS; SCALP HAIR; SELENIUM; COPPER; BLOOD; ZINC; EXPOSURE; METALS; TISSUE; PLASMA;

D O I：

10.3390/nu11010037

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The relationships between serum levels of trace elements and breast cancer remain relatively unknown. In this study, we investigate serum levels of seven trace elements in Korean breast cancer patients compared to controls without breast cancer. Serum trace element levels were determined using inductively coupled plasma mass spectrometry in Korean breast cancer patients before initiation of breast cancer treatment. Korean females without breast cancer served as a control group. Trace element levels were measured in the discovery cohort (n = 287) and were validated in an independent cohort (n = 142). We further investigated possible associations between trace element levels and the presence of lymph node metastasis, distant metastasis, or triple-negative breast cancer among breast cancer patients in subgroup analyses. Serum manganese and molybdenum levels were significantly higher (p < 0.05) in breast cancer patients than in controls. Serum copper levels were significantly higher in breast cancer patients with distant metastasis, while selenium levels were significantly lower. Other trace elements were neither significantly different between breast cancer patients and controls nor between subgroups of breast cancer patients. Our study provides insights about the potential roles and impacts of trace elements through an assessment of the associations between trace elements and breast cancer.

引用

页数：15

共 43 条

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