Lowering Low-Density Lipoprotein Cholesterol: Statins, Ezetimibe, Bile Acid Sequestrants, and Combinations: Comparative Efficacy and Safety

被引：77

作者：

Hou, Runhua ^{[2
]}

Goldberg, Anne Carol ^{[1
]}

机构：

[1] Washington Univ, Div Endocrinol Metab & Lipid Res, Sch Med, St Louis, MO 63110 USA

[2] Univ Rochester, Endocrine Unit, Rochester, NY 14642 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2009年 / 38卷 / 01期

关键词：

LDL-C; Statins; Ezetimibe; Bile acid sequestrants; Efficacy; Safety; CORONARY-ARTERY-DISEASE; EXTENDED-RELEASE NIACIN; COLESEVELAM HYDROCHLORIDE; PRIMARY HYPERCHOLESTEROLEMIA; COMBINED HYPERLIPIDEMIA; DOUBLE-BLIND; FAMILIAL HYPERCHOLESTEROLEMIA; ENTEROHEPATIC CIRCULATION; ABSORPTION INHIBITOR; LOVASTATIN THERAPY;

D O I：

10.1016/j.ecl.2008.11.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins, ezetimibe, and bile acid-binding resins can be used individually or in combination for lowering low-density lipoprotein cholesterol (LDL-C) levels. Statins are the most potent drugs for lowering LDL-C and are well tolerated in most patients. The addition of a bile acid sequestrant or ezetimibe to a statin produces additional LDL-C reduction allowing many patients to reach LDL-C targets. This article discusses the efficacy and safety of available statins, bile acid sequestrants, and ezetimibe in the treatment of hyperlipidemia.

引用

页码：79 / +

页数：20

共 98 条

[1] Colesevelam hydrochloride: A novel bile acid-binding resin [J].

Aldridge, MA ;

Ito, MK .

ANNALS OF PHARMACOTHERAPY, 2001, 35 (7-8) :898-907

[2] Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption [J].

Altmann, SW ;

Davis, HR ;

Zhu, LJ ;

Yao, XR ;

Hoos, LM ;

Tetzloff, G ;

Iyer, SPN ;

Maguire, M ;

Golovko, A ;

Zeng, M ;

Wang, LQ ;

Murgolo, N ;

Graziano, MP .

SCIENCE, 2004, 303 (5661) :1201-1204

[3] Standards of medical care in diabetes 2008 [J].

不详 .

DIABETES CARE, 2008, 31 :S12-S54

[4]

[Anonymous], LANCET

[5] EFFECTS OF LOVASTATIN THERAPY ON VERY-LOW-DENSITY LIPOPROTEIN TRIGLYCERIDE-METABOLISM IN SUBJECTS WITH COMBINED HYPERLIPIDEMIA - EVIDENCE FOR REDUCED ASSEMBLY AND SECRETION OF TRIGLYCERIDE-RICH LIPOPROTEINS [J].

ARAD, Y ;

RAMAKRISHNAN, R ;

GINSBERG, HN .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1992, 41 (05) :487-493

[6]

ARAD Y, 1990, J LIPID RES, V31, P567

[7]

*ASTRAZENECA, CRESTOR ROS CALC US

[8] Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins [J].

Baigent, C ;

Keech, A ;

Kearney, PM ;

Blackwell, L ;

Buck, G ;

Pollicino, C ;

Kirby, A ;

Sourjina, T ;

Peto, R ;

Collins, R ;

Simes, J .

LANCET, 2005, 366 (9493) :1267-1278

[9] Efficacy and safety of rosuvastatin 40 mg alone or in combination with ezetimibe in patients at high risk of cardiovascular disease (Results from the EXPLORER study) [J].

Ballantyne, Christie M. ;

Weiss, Robert ;

Moccetti, Tiziano ;

Vogt, Anja ;

Eber, Bernd ;

Sosef, Froukje ;

Duffield, Emma .

AMERICAN JOURNAL OF CARDIOLOGY, 2007, 99 (05) :673-680

[10] Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia - A prospective, randomized, double-blind trial [J].

Ballantyne, CM ;

Houri, J ;

Notarbartolo, A ;

Melani, L ;

Lipka, LJ ;

Suresh, R ;

Sun, S ;

LeBeaut, AP ;

Sager, PT ;

Veltri, EP .

CIRCULATION, 2003, 107 (19) :2409-2415

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