Four new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

被引：38

作者：

Dai, Sheng-Jun ^{[1
]}

Chen, Meng ^{[1
]}

Liu, Ke ^{[1
]}

Jiang, Yong-Tao ^{[1
]}

Shen, Li ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 06期

关键词：

Labiatae; Scutellaria barbata; Scutebarbatine C; Scutebarbatine D; Scutebarbatine E; Scutebarbatine F;

D O I：

10.1248/cpb.54.869

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures were elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC50 values in the range 3.9-7.8 mu m.

引用

页码：869 / 872

页数：4

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