Advances in D-Amino Acids in Neurological Research

被引：46

作者：

Seckler, James M. ^{[1
]}

Lewis, Stephen J. ^{[2
]}

机构：

[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 19期

关键词：

d-amino acids; brain; Alzheimer; schizophrenia; neurological disorders; N-methyl-D-aspartate (NMDA) receptor; D-ASPARTIC ACID; FREE D-SERINE; CENTRAL-NERVOUS-SYSTEM; REDUCE INFARCT VOLUME; POLY-ARGININE R18; D-METHIONINE; HYDROGEN-SULFIDE; NMDA RECEPTORS; D-ALANINE; CEREBROSPINAL-FLUID;

D O I：

10.3390/ijms21197325

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-amino acids have been known to exist in the human brain for nearly 40 years, and they continue to be a field of active study to today. This review article aims to give a concise overview of the recent advances in D-amino acid research as they relate to the brain and neurological disorders. This work has largely been focused on modulation of the N-methyl-D-aspartate (NMDA) receptor and its relationship to Alzheimer's disease and Schizophrenia, but there has been a wealth of novel research which has elucidated a novel role for several D-amino acids in altering brain chemistry in a neuroprotective manner. D-amino acids which have no currently known activity in the brain but which have active derivatives will also be reviewed.

引用

页码：1 / 20

页数：19

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