共 32 条
[31]
Identification of the C4′-Oxidized Abasic Site as the Most Abundant 2-Deoxyribose Lesion in Radiation-Damaged DNA Using a Novel HPLC-Based Approach
[J].
Roginskaya, Marina
;
Mohseni, Reza
;
Moore, Terence J.
;
Bernhard, William A.
;
Razskazovskiy, Yuriy
.
RADIATION RESEARCH,
2014, 181 (02)
:131-137

Roginskaya, Marina
论文数: 0 引用数: 0
h-index: 0
机构:
E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA

Mohseni, Reza
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h-index: 0
机构:
E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA

Moore, Terence J.
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机构:
E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA

Bernhard, William A.
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机构:
Univ Rochester, Med Ctr, Dept Biochem & Biophys, Rochester, NY 14642 USA E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA

Razskazovskiy, Yuriy
论文数: 0 引用数: 0
h-index: 0
机构:
E Tennessee State Univ, Dept Phys & Astron, Johnson City, TN 37614 USA E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA
[32]
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
[J].
Kung, Pei-Pei
;
Bingham, Patrick
;
Brooun, Alexei
;
Collins, Michael
;
Deng, Ya-Li
;
Dinh, Dac
;
Fan, Connie
;
Gajiwala, Ketan S.
;
Grantner, Rita
;
Gukasyan, Hovhannes J.
;
Hu, Wenyue
;
Huang, Buwen
;
Kania, Robert
;
Kephart, Susan E.
;
Krivacic, Cody
;
Kumpf, Robert A.
;
Khamphavong, Penney
;
Kraus, Manfred
;
Liu, Wei
;
Maegley, Karen A.
;
Nguyen, Lisa
;
Ren, Shijian
;
Richter, Dan
;
Rollins, Robert A.
;
Sach, Neal
;
Sharma, Shikhar
;
Sherrill, John
;
Spangler, Jillian
;
Stewart, Albert E.
;
Sutton, Scott
;
Uryu, Sean
;
Verhelle, Dominique
;
Wang, Hui
;
Wang, Shuiwang
;
Wythes, Martin
;
Xin, Shuibo
;
Yamazaki, Shinji
;
Zhu, Huichun
;
Zhu, JinJiang
;
Zehnder, Luke
;
Edwards, Martin
.
JOURNAL OF MEDICINAL CHEMISTRY,
2018, 61 (03)
:650-665

Kung, Pei-Pei
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Bingham, Patrick
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Brooun, Alexei
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Collins, Michael
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Deng, Ya-Li
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Dinh, Dac
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Fan, Connie
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Gajiwala, Ketan S.
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Grantner, Rita
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Gukasyan, Hovhannes J.
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Pfizer Global Res & Dev, La Jolla Labs, Pharmaceut Sci Res Enabling Grp, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Hu, Wenyue
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Pfizer Global Res & Dev, La Jolla Labs, Drug Safety Res & Dev, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Huang, Buwen
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Kania, Robert
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Kephart, Susan E.
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Krivacic, Cody
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Kumpf, Robert A.
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Khamphavong, Penney
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Pfizer Global Res & Dev, La Jolla Labs, Pharmaceut Sci Res Enabling Grp, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Kraus, Manfred
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Liu, Wei
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Maegley, Karen A.
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Nguyen, Lisa
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Ren, Shijian
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WuXi AppTec, 288 Fute Zhong Rd, Shanghai 200131, Peoples R China Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Richter, Dan
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Rollins, Robert A.
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA
Pfizer Global Res & Dev, 401 N Middletown Rd, Pearl River, NY 10965 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Sach, Neal
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Sharma, Shikhar
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Sherrill, John
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Spangler, Jillian
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Stewart, Albert E.
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Sutton, Scott
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Uryu, Sean
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Verhelle, Dominique
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Wang, Hui
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Res Unit, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Wang, Shuiwang
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WuXi AppTec, 288 Fute Zhong Rd, Shanghai 200131, Peoples R China Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Wythes, Martin
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Xin, Shuibo
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WuXi AppTec, 288 Fute Zhong Rd, Shanghai 200131, Peoples R China Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Yamazaki, Shinji
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Pfizer Global Res & Dev, La Jolla Labs, Pharmacokinet Dynam & Metab, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Zhu, Huichun
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Zhu, JinJiang
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Zehnder, Luke
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA

Edwards, Martin
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Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA Pfizer Global Res & Dev, La Jolla Labs, Oncol Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA