Dissecting signaling and functions of adhesion G protein-coupled receptors

被引：35

作者：

Arac, Demet ^{[1
]}

Aust, Gabriela ^{[2
]}

Calebiro, Davide ^{[3
,4
]}

Engel, Felix B. ^{[5
,6
]}

Formstone, Caroline ^{[7
]}

Goffinet, Andre ^{[8
]}

Hamann, Joerg ^{[9
]}

Kittel, Robert J. ^{[10
]}

Liebscher, Ines ^{[11
]}

Lin, Hsi-Hsien ^{[12
]}

Monk, Kelly R. ^{[13
]}

Petrenko, Alexander ^{[14
]}

Piao, Xianhua ^{[15
,16
]}

Proemel, Simone ^{[11
]}

Schioth, Helgi B. ^{[17
]}

Schwartz, Thue W. ^{[18
,19
]}

Stacey, Martin ^{[20
]}

Ushkaryov, Yuri A. ^{[21
,22
]}

Wobus, Manja ^{[23
]}

Wolfrum, Uwe ^{[24
]}

Xu, Lei ^{[25
]}

Langenhan, Tobias ^{[10
]}

机构：

[1] Stanford Univ, Stanford, CA 94305 USA

[2] Univ Leipzig, Dept Surg, Res Labs, D-04109 Leipzig, Germany

[3] Univ Wurzburg, DFG Res Ctr Expt Biomed, Inst Pharmacol, D-97070 Wurzburg, Germany

[4] Univ Wurzburg, DFG Res Ctr Expt Biomed, Rudolf Virchow Ctr, D-97070 Wurzburg, Germany

[5] Max Planck Inst Heart & Lung Res, Dept Cardiac Dev & Remodelling, Bad Nauheim, Germany

[6] Univ Erlangen Nurnberg, Inst Pathol, Dept Nephropathol, Lab Expt Renal & Cardiovasc Res, Erlangen, Germany

[7] Kings Coll London, MRC Ctr Dev Neurobiol, London, England

[8] Catholic Univ Louvain, Inst Neurosci, B-1200 Brussels, Belgium

[9] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1105 AZ Amsterdam, Netherlands

[10] Univ Wurzburg, Dept Neurophysiol, Inst Physiol, D-97070 Wurzburg, Germany

[11] Univ Leipzig, Fac Med, Inst Biochem, D-04109 Leipzig, Germany

[12] Chang Gung Univ, Coll Med, Dept Microbiol & Immunol, Tao Yuan, Taiwan

[13] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO USA

[14] Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia

[15] Boston Childrens Hosp, Dept Med, Div Newborn Med, Boston, MA USA

[16] Harvard Univ, Sch Med, Boston, MA USA

[17] Uppsala Univ, Dept Neurosci, Uppsala, Sweden

[18] Univ Copenhagen, Dept Neurosci & Pharmacol, Mol Pharmacol Lab, Copenhagen, Denmark

[19] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark

[20] Univ Leeds, Fac Biol Sci, Leeds, W Yorkshire, England

[21] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, London, England

[22] Univ Kent, Medway Sch Pharm, Chatham, Kent, England

[23] Univ Hosp Carl Gustav Carus, Med Clin & Policlin 1, Dresden, Germany

[24] Johannes Gutenberg Univ Mainz, Inst Zool, Mainz, Germany

[25] Univ Rochester, Med Ctr, Rochester, NY 14642 USA

来源：

ANNALS MEETING REPORTS 2013 | 2012年 / 1276卷

关键词：

G protein-coupled receptors; GPS motif; autoproteolysis; molecular and genetic analysis; CALCIUM-INDEPENDENT RECEPTOR; ALPHA-LATROTOXIN-BINDING; PLANAR CELL POLARITY; PROTEOLYTIC CLEAVAGE; GPCR EMR2; CD97; GPR56; LATROPHILIN; CELSR1; FAMILY;

D O I：

10.1111/j.1749-6632.2012.06820.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

G protein-coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein-coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, alpha-subunit) and C-terminal fragment (CTF, CT, beta-subunit) at a conserved GPCR autoproteolysis-inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The "6th International Adhesion-GPCR Workshop," held at the Institute of Physiology of the University of Wurzburg on September 6-8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.

引用

页码：1 / 25

页数：25

共 80 条

[1] A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis [J].