Kidney Cancer: Now Available in a New Flavor

被引：25
作者：
Kaelin, William G., Jr. [1 ,2 ]
机构：
[1] Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
CANCER CELL | 2008年 / 14卷 / 06期
关键词：
D O I：
10.1016/j.ccr.2008.11.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of the von Hippel-Lindau tumor suppressor protein (pVHL) in kidney cancer has provided a rationale for treating this disease with hypoxia-inducible factor (HIF) antagonists. In this issue, Simon and coworkers show that the molecular signature of VHL(-/-) kidney cancers is profoundly influenced by whether they produce both HIF2 alpha and HIF1 alpha or HIF2 alpha alone.
引用
收藏
页码：423 / 424
页数：2
相关论文
共 12 条
[1]   Targeted replacement of hypoxia-inducible factor-1α by a hypoxia-inducible factor-2α knock-in allele promotes tumor growth [J].
Covello, KL ;
Simon, MC ;
Keith, B .
CANCER RESEARCH, 2005, 65 (06) :2277-2286
[2]   HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity [J].
Gordan, John D. ;
Bertout, Jessica A. ;
Hu, Cheng-Jun ;
Diehl, J. Alan ;
Simon, M. Celeste .
CANCER CELL, 2007, 11 (04) :335-347
[3]   HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma [J].
Gordan, John D. ;
Lal, Priti ;
Dondeti, Vijay R. ;
Letrero, Richard ;
Parekh, Krishna N. ;
Oquendo, C. Elisa ;
Greenberg, Roger A. ;
Flaherty, Keith T. ;
Rathmell, W. Kimryn ;
Keith, Brian ;
Simon, M. Celeste ;
Nathanson, Katherine L. .
CANCER CELL, 2008, 14 (06) :435-446
[4]   The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer [J].
Kaelin, William G., Jr. .
NATURE REVIEWS CANCER, 2008, 8 (11) :865-873
[5]   Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway [J].
Kaelin, William G., Jr. ;
Ratcliffe, Peter J. .
MOLECULAR CELL, 2008, 30 (04) :393-402
[6]   Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo [J].
Kim, William Y. ;
Safran, Michal ;
Buckley, Marshall R. M. ;
Ebert, Benjamin L. ;
Glickman, Jonathan ;
Bosenberg, Marcus ;
Regan, Meredith ;
Kaelin, William G., Jr. .
EMBO JOURNAL, 2006, 25 (19) :4650-4662
[7]   Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth [J].
Kondo, K ;
Kim, WY ;
Lechpammer, M ;
Kaelin, WG .
PLOS BIOLOGY, 2003, 1 (03) :439-444
[8]   Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein [J].
Kondo, K ;
Klco, J ;
Nakamura, E ;
Lechpammer, M ;
Kaelin, WG .
CANCER CELL, 2002, 1 (03) :237-246
[9]   HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron [J].
Mandriota, SJ ;
Turner, KJ ;
Davies, DR ;
Murray, PG ;
Morgan, NV ;
Sowter, HM ;
Wykoff, CC ;
Maher, ER ;
Harris, AL ;
Ratcliffe, PJ ;
Maxwell, PH .
CANCER CELL, 2002, 1 (05) :459-468
[10]   The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma [J].
Maranchie, JK ;
Vasselli, JR ;
Riss, J ;
Bonifacino, JS ;
Linehan, WM ;
Klausner, RD .
CANCER CELL, 2002, 1 (03) :247-255
12