Functional CD32 molecules on human NK cells

Human NK cells are large granular lymphocytes that kill neoplastic or virally infected targets using perforin-dependent mechanisms. CD16 or Fc gamma RIII is one of the cell surface molecules that can trigger the killing machinery following binding of the Fc portion of IgG to the receptor: a mechanism known as antibody dependent cell-mediated cytotoxicity (ADCC). We have recently shown that some individuals express an additional Fc gamma R on their NK cells, CD32 or Fc gamma RII. This receptor has now been characterized at the molecular, biochemical and functional level. The present review outlines our findings to date on the features of this novel receptor. These findings suggest that the presence of a functional Fc gamma RII on the surface of NK cells could have important clinical consequences in both turner immunotherapy and autoimmune disease.