Development of metabotropic glutamate receptor-mediated synaptic inhibition

被引：12

作者：

Dumas, TC ^{[1
]}

Foster, TC ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT PSYCHOL,CHARLOTTESVILLE,VA 22903

来源：

NEUROREPORT | 1997年 / 8卷 / 13期

关键词：

CA3-CA1; hippocampus; mGluR; paired-pulse facilitation; postnatal development; postsynaptic; presynaptic; rat;

D O I：

10.1097/00001756-199709080-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MODULATION of hippocampal CA3-CA1 synaptic transmission during metabotropic glutamate receptor (mGluR) activation was investigated in juvenile (post-natal day (P) 15-21) and young adult rats (P28-35). The mGluR agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) depressed the EPSP slope more in young adults than juveniles. ACPD increased paired-pulse facilitation (PPF) at both ages. The group I mGluR antagonist (+)-alpha-methylcarboxyphenylglycine (MCPG) inhibited the ACPD-mediated depression of the EPSP slope and completely blocked the increase in PPF only in young adults. Minimal effects of MCPG on ACPD-dependent synaptic depression were observed in juveniles. These data suggest that presynaptic group I mGluR-mediated synaptic inhibition increases across late postnatal development. In addition, other mGluR subtypes, with the ability to depress presynaptic function, appear to be present in juveniles.

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收藏

页码：2919 / 2924

页数：6

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