An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines

被引：9
作者：
Balalaie, Saeed [1 ]
Ashouriha, Morteza [1 ]
Rominger, Frank [2 ]
Bijanzadeh, Hamid Reza [1 ,3 ]
机构：
[1] KN Toosi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran
[2] Heidelberg Univ, Inst Organ Chem, D-69120 Heidelberg, Germany
[3] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
来源：
MOLECULAR DIVERSITY | 2013年 / 17卷 / 01期
基金：
美国国家科学基金会;
关键词：
Multicomponant reactions; Enaminones; 3-Amino-5-chromenyl-butenolides; Chromones; MCR; CANCER-THERAPY; AQUEOUS-MEDIA; INHIBITORS; AGENTS; DNA; PRODUCTS; TARGETS;
D O I：
10.1007/s11030-013-9423-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A three-component reaction of 3-formyl chromones, dialkyl acetylenedicarboxylate, and isocyanides in the presence of was used as a highly efficient and practical approach for the synthesis of 3-amino-5-chromenyl-butenolides. High yields and high bond forming efficiency, and simple operations are the advantages of this method. Graphical abstract.
引用
收藏
页码：55 / 61
页数：7
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