Emerging oral anticoagulants for stroke prevention in patients with non-valvular atrial fibrillation

被引：0

作者：

Destephan, C.

Waller, A. H.

Patel, R. J.

Dhruvakumar, S.

Mazza, V.

Gerula, C.

Maher, J.

Kaluski, E.

机构：

[1] Univ Hosp, Dept Med, Div Cardiol, Newark, NJ USA

[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA

来源：

MINERVA CARDIOANGIOLOGICA | 2012年 / 60卷 / 04期

关键词：

Atrial fibrillation ablation; Warfarin; Stroke; DABIGATRAN ETEXILATE; WARFARIN; RIVAROXABAN; HEMORRHAGE; REVERSAL; RISK;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In patients with atrial fibrillation (AF) warfarin has been the mainstay therapy for stroke prevention. In recent randomized clinical trials (RCTs) oral direct thrombin inhibitor (Dabigatran) and factor Xa inhibitors (Rivaroxaban and Apixaban) challenged the efficacy and safety benchmarks set by warfarin. These drugs boast a rapid onset of action, shorter half-life and fewer drug and dietary interactions. Moreover, these new anticoagulants do not require monitoring, titration or dose adjustments. These agents have already been approved for prevention of stroke or systemic embolism in patients with AF. Uncertainty regarding suitability, efficacy and safety in certain patient subsets and issues related to the ability effectively monitor the pharmacodynamic effects and reverse the therapeutic effects of these drugs should be addressed as we engage in a widespread use of these agents in various patient subsets.

引用

页码：425 / 431

页数：7

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