Determination of platinum derived from cisplatin in human tissues using electrospray ionization mass spectrometry

被引：24

作者：

Minakata, K ^{[1
]}

Nozawa, H ^{[1
]}

Okamoto, N ^{[1
]}

Suzuki, O ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Legal Med, Hamamatsu, Shizuoka 4313192, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2006年 / 832卷 / 02期

关键词：

platinum; electrospray ionization; mass spectrometry Diethyldithiocarbamate; silver;

D O I：

10.1016/j.jchromb.2006.01.016

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Determination of platinum (Pt) derived from cisplatin in tissues was performed by electrospray ionization mass spectrometry (ESI-MS) using silver (Ag) as the internal standard. Pt and Ag reacted with diethyldithiocarbamate (DDC), and were extracted using isoamylalcohol and acidified with oxalic acid. The compounds were termed Pt(DDC)(3)(+) and Ag(DDC)(2)(+), based on their m/z values exhibiting the highest peaks at m/z 639 and m/z 405, respectively. The limit of detection was 30 pg and the quantitation range was from 100 to 10,000 pg using 5 mg tissue. The present method allowed the determination of Pt in wet-ashed tissue in 10 min. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：286 / 291

页数：6

共 14 条

[1] URINE ANALYSIS OF PLATINUM SPECIES DERIVED FROM CIS-DICHLORODIAMMINEPLATINUM(II) BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOLLOWING DERIVATIZATION WITH SODIUM DIETHYLDITHIOCARBAMATE [J].

BANNISTER, SJ ;

STERNSON, LA ;

REPTA, AJ .

JOURNAL OF CHROMATOGRAPHY, 1979, 173 (02) :333-342

[2] ICP-MS determination of Pt in biological fluids of patients treated with antitumor agents: evaluation of analytical uncertainty [J].

Bettinelli, M .

MICROCHEMICAL JOURNAL, 2005, 79 (1-2) :357-365

[3]

Bonfiglio R, 1999, RAPID COMMUN MASS SP, V13, P1175, DOI 10.1002/(SICI)1097-0231(19990630)13:12<1175::AID-RCM639>3.3.CO

[4]

2-S

[5]

CHU G, 1993, CANCER, V72, P3707, DOI 10.1002/1097-0142(19931215)72:12<3707::AID-CNCR2820721224>3.0.CO

[6]

2-U

[7] CISPLATIN-INDUCED LOSS OF KIDNEY COPPER AND NEPHROTOXICITY IS AMELIORATED BY SINGLE DOSE DIETHYLDITHIOCARBAMATE, BUT NOT MESNA [J].

DEWOSKIN, RS ;

RIVIERE, JE .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1992, 112 (02) :182-189

[8] QUANTITATIVE-DETERMINATION OF UNCHANGED CISPLATIN IN RAT-KIDNEY AND LIVER BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

HANADA, K ;

NAGAI, N ;

OGATA, H .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 663 (01) :181-186

[9] Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry [J].

Hsieh, YS ;

Chintala, M ;

Mei, H ;

Agans, J ;

Brisson, JM ;

Ng, K ;

Korfmacher, WA .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2001, 15 (24) :2481-2487

[10] Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge [J].

Lenz, K ;

Hann, S ;

Koellensperger, G ;

Stefanka, Z ;

Stingeder, G ;

Weissenbacher, N ;

Mahnik, SN ;

Fuerhacker, M .

SCIENCE OF THE TOTAL ENVIRONMENT, 2005, 345 (1-3) :141-152

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