The multiple roles of phosphoinositide 3-kinase in mast cell biology

被引：111
作者：
Kim, Mi-Sun [1 ]
Radinger, Madeleine [1 ]
Gilfillan, Alasdair M. [1 ]
机构：
[1] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA
来源：
TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 10期
关键词：
D O I：
10.1016/j.it.2008.07.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mast cells play a central role in the initiation of inflammatory responses associated with asthma and other allergic disorders. Receptor-mediated mast cell growth, differentiation, homing to their target tissues, survival and activation are all controlled, to varying degrees, by phosphoinositide-3-kinase (PI3K)-driven pathways. It is not fully understood how such diverse responses can be differentially regulated by PI3K. However, recent studies have provided greater insight into the mechanisms that control, and those that are controlled by, different PI3K subunit isoforms in mast cells. In this review, we discuss how PI3K influences the mast cell processes described above. Furthermore, we describe how different mast cell receptors use alternative isoforms of PI3K for these functions and discuss potential downstream targets of these isoforms.
引用
收藏
页码：493 / 501
页数：9
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