Mechanisms of disease - Glucose transporters and insulin action - Implications for insulin resistance and diabetes mellitus

被引:961
作者
Shepherd, PR
Kahn, BB
机构
[1] Beth Israel Deaconess Med Ctr, Diabet Unit, Dept Med, Boston, MA 02215 USA
[2] UCL, Dept Biochem & Mol Biol, London, England
[3] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1056/NEJM199907223410406
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:248 / 257
页数:10
相关论文
共 106 条
[1]  
Abel E. Dale, 1996, P530
[2]   Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes [J].
Ahmad, F ;
Azevedo, JL ;
Cortright, R ;
Dohm, GL ;
Goldstein, BJ .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (02) :449-458
[3]   Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].
Alessi, DR ;
James, SR ;
Downes, CP ;
Holmes, AB ;
Gaffney, PRJ ;
Reese, CB ;
Cohen, P .
CURRENT BIOLOGY, 1997, 7 (04) :261-269
[4]  
Bailey C.J., 1997, CURRENT OPINION ENDO, V4, P40
[5]   Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle - Implications for glucose toxicity [J].
Baron, AD ;
Zhu, JS ;
Weldon, H ;
Maianu, L ;
Garvey, WT .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (06) :2792-2801
[6]   INSULIN RESISTANCE IN SKELETAL-MUSCLES IN PATIENTS WITH NIDDM [J].
BECKNIELSEN, H ;
VAAG, A ;
DAMSBO, P ;
HANDBERG, A ;
NIELSEN, OH ;
HENRIKSEN, JE ;
THYERONN, P .
DIABETES CARE, 1992, 15 (03) :418-429
[7]   Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a PI3-kinase mediated effect [J].
Berti, L ;
Kellerer, M ;
Capp, E ;
Haring, HU .
DIABETOLOGIA, 1997, 40 (05) :606-609
[8]   GENETIC-VARIANTS IN PROMOTERS AND CODING REGIONS OF THE MUSCLE GLYCOGEN-SYNTHASE AND THE INSULIN-RESPONSIVE GLUT4 GENES IN NIDDM [J].
BJORBAEK, C ;
ECHWALD, SM ;
HUBRICHT, P ;
VESTERGAARD, H ;
HANSEN, T ;
ZIERATH, J ;
PEDERSEN, O .
DIABETES, 1994, 43 (08) :976-983
[9]   Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation [J].
Bjornholm, M ;
Kawano, Y ;
Lehtihet, M ;
Zierath, JR .
DIABETES, 1997, 46 (03) :524-527
[10]   Role of fatty acids in the pathogenesis of insulin resistance and NIDDM [J].
Boden, G .
DIABETES, 1997, 46 (01) :3-10