Chemistry and Bioactivity of Briaranes from the South China Sea Gorgonian Dichotella gemmacea

被引：12

作者：

Li, Cui ^{[1
,2
]}

La, Ming-Ping ^{[1
]}

Tang, Hua ^{[1
]}

Sun, Peng ^{[1
]}

Liu, Bao-Shu ^{[1
]}

Zhuang, Chun-Lin ^{[1
]}

Yi, Yang-Hua ^{[1
]}

Zhang, Wen ^{[1
]}

机构：

[1] Second Mil Med Univ, Res Ctr Marine Drugs, Sch Pharm, 325 Guo He Rd, Shanghai 200433, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Sci & Res Lab, Longhua Hosp, 725 South Wanping Rd, Shanghai 200032, Peoples R China

来源：

MARINE DRUGS | 2016年 / 14卷 / 11期

关键词：

briarane diterpenoids; biological activity; structure elucidation; gorgonian; Dichotella gemmacea; CORAL JUNCEELLA-FRAGILIS; SECONDARY METABOLITES; DITERPENOIDS; GROWTH;

D O I：

10.3390/md14110201

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new briarane diterpenoids, gemmacolides AZ-BF (1-7), were isolated together with eight known analogues (8-15) from the South China gorgonian Dichotella gemmacea. Their structures were elucidated based on detailed spectroscopic analysis and a comparison with reported data. In an in vitro bioassay, these compounds exhibited different levels of growth inhibition activity against A549 and MG63 cells, giving continuous evidences about the biological contribution of functional groups at C-2, C-12, C-13, and C-16. These compounds were also evaluated for their antibacterial and antifungal activities. Compound 8 exhibited a potential antibacterial activity against both Gram-positive bacterium Bacillus megaterium and Gram-negative bacterium Escherichia coli.

引用

页数：11

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