Tailoring cAMP-signalling responses through isoform multiplicity

被引：391
作者：
Houslay, MD
Milligan, G
机构：
[1] Molecular Pharmacology Group, Inst. of Life and Biomed. Sciences, University of Glasgow, Glasgow
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 06期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S0968-0004(97)01050-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Multiple forms of cAMP phosphodiesterases (PDE), adenylate cyclase and protein kinase A (PKA) allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for its dynamic adjustment. Multiple forms of these enzymes confer spatial anti temporal characteristics on cAMP signalling so as to affect compartmentalised responses within a single cell type. The ability to breach the PKA activation threshold can depend upon either or both the activation of adenylate cyclase and inhibition of specific PDE isoforms.
引用
收藏
页码：217 / 224
页数：8
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