In Ethiopia, the common bean (Phaseolus vulgaris L.) is an important grain legume with a high food and commercial value. Yet, its productivity is very low, which could be attributed to low levels of soil organic matter, nitrogen (N), phosphorous (P), sulfur (S), and boron (B), and insufficient fertilizer application. Therefore, a field experiment was conducted during the 2019 cropping season in Alle, Southern Ethiopia, to evaluate the agronomic and economic responses of blended NPSB (18.7N-37.4P2O5-6.9S-0.25B) and farmyard manure (FYM) for common bean production. Four NPSB-blended fertilizer rates (0, 50, 100, and 150 kg center dot ha(-1)) and three FYM rates (0, 2.5, and 5 tons center dot ha(-1)) were used in the experiment. The experiment was laid out using a randomized complete block design in a factorial arrangement with four replications. The result showed that NPSB and FYM significantly affected crop phenology, growth, yield, and yield components. Application of 100 kg center dot ha(-1) NPSB along with 5 t center dot ha(-1) FYM significantly increased the number of nodules, hundred seed weight, and grain production. The results also showed that using 100 kg center dot ha(-1) NPSB fertilizer in combination with 5 t center dot ha(-1) FYM produced the highest grain, which is about 173% higher grain yield than the control. Partial budget analysis indicated that application of 100 kg center dot ha(-1) NPSB fertilizer with 5 t center dot ha(-1) FYM resulted in the highest marginal rate of return (1308%) and the best net profit. Therefore, an integrated application of 100 kg center dot ha(-1) NPSB fertilizer and 5 t center dot ha(-1) FYM is suggested.