Osteosarcoma

被引：194

作者：

Eaton, Bree R. ^{[1
]}

Schwarz, Rudolf ^{[2
]}

Vatner, Ralph ^{[3
]}

Yeh, Brian ^{[4
]}

Claude, Line ^{[5
]}

Indelicato, Daniel J. ^{[6
]}

Laack, Nadia ^{[7
]}

机构：

[1] Emory Univ, Winship Canc Inst, Radiat Oncol, Atlanta, GA 30322 USA

[2] Univ Med Ctr Hamburg Eppendorf, Outpatient Ctr, Radiotherapy & Radiooncol, Hamburg, Germany

[3] Univ Cincinnati, Radiat Oncol, Cincinnati, OH USA

[4] Mt Sinai Hosp, Radiat Oncol, New York, NY 10029 USA

[5] Ctr Leon Berard, Radiat Oncol, Lyon, France

[6] Univ Florida, Coll Med, Radiat Oncol, Jacksonville, FL USA

[7] Mayo Clin, Radiat Oncol, Rochester, MN USA

来源：

PEDIATRIC BLOOD & CANCER | 2021年 / 68卷

关键词：

chemotherapy; metastasis; osteosarcoma; radiotherapy; surgery; HIGH-GRADE OSTEOSARCOMA; SOFT-TISSUE SARCOMA; LIMB-SALVAGE; NONMETASTATIC OSTEOSARCOMA; NEOADJUVANT CHEMOTHERAPY; LOCAL RECURRENCE; OPEN-LABEL; METASTATIC OSTEOSARCOMA; PULMONARY METASTASES; MURAMYL TRIPEPTIDE;

D O I：

10.1002/pbc.28352

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteosarcoma is a rare tumor that requires complex multidisciplinary management. This paper reviews the general management and standard radiotherapy guidelines for osteosarcoma in both North America and Europe in a joined effort between the Children's Oncology Group and International Society of Pediatric Oncology. Standard treatment involves multiagent induction chemotherapy followed by surgical resection for local tumor control and consolidation local control to metastatic sites. Radiotherapy is reserved for cases with a marginal or incomplete resection or for definitive treatment in the case of unresectable disease. We present supporting data for the role of chemotherapy, surgery, and radiation therapy.

引用

页数：7

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