Clinical Determinants of Quality of Life in Patients With Acute Decompensated Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT-Heart Failure With Preserved Ejection Fraction Registry

Improvement of quality of life (QOL) is one of the most important clinical end points for patients with heart failure (HF).1 As our society continues to age, patients with HF are placing increasing value on better QOL over prolonged survival. Thus, physicians should place increasing awareness toward improving QOL in the management of HF. The prevalence of HF with preserved ejection fraction (HFpEF) is rapidly increasing worldwide and the condition is becoming a growing issue as patients with HFpEF are generally old and often have multiple comorbidities. It is, therefore, clinically relevant to identify aggravating factors of QOL among cardiac factors and noncardiac comorbidities comprehensively, to specify appropriate therapeutic targets in HFpEF. Although several previous studies of HFpEF in the United States have already identified clinical correlates of adverse QOL,2 the results might vary depending on geography, considering the wide diversity and regionality of HFpEF. Therefore, we aimed to identify the factors associated with impaired QOL in Japanese patients with HFpEF. © 2022 The Authors.