Expeditious Synthesis of Tetrasubstituted Helical Alkenes by a Cascade of Palladium-Catalyzed C-H Activations

被引：114
作者：
Liu, Hongqiang [1 ]
El-Salfiti, Mohamed [1 ]
Lautens, Mark [1 ]
机构：
[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 39期
基金：
加拿大自然科学与工程研究理事会;
关键词：
C?H activation; domino reactions; palladium; strained molecules; tetrasubstituted alkenes; STEREOSELECTIVE-SYNTHESIS; MOLECULAR SWITCHES; NORBORNENE;
D O I：
10.1002/anie.201204226
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular domino process allows the formation of three C-C bonds in one operation through a C-H activation/carbopalladation/C-H activation sequence. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9846 / 9850
页数：5
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