Molecular spectrum of thalassemia in tropical Hainan Island of southern China: high allele frequency with low health burden

被引：6
作者：
Lai, Yanquan [1 ]
Tao, Fangchao [2 ]
Zou, Yu [3 ]
Huang, Min [3 ]
Lin, Kaiting [4 ]
Li, Yang [2 ]
Huang, Weilun [2 ]
Zhou, Wanjun [2 ,5 ]
机构：
[1] Hainan Prov Publ Serv Ctr Prenatal & Postnatal Car, Dept Eugenics, Haikou 570203, Hainan, Peoples R China
[2] Southern Med Univ, Sch Basic Med Sci, Dept Med Genet, Guangzhou 510515, Guangdong, Peoples R China
[3] Hainan Prov Publ Serv Ctr Prenatal & Postnatal Car, Dept Clin Lab, Haikou 570203, Hainan, Peoples R China
[4] Danzhou Family Planning Serv Ctr, Danzhou 571799, Hainan, Peoples R China
[5] Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou 510515, Guangdong, Peoples R China
来源：
JOURNAL OF GENETICS AND GENOMICS | 2022年 / 49卷 / 12期
关键词：
MALARIA; ALPHA; GENE;
D O I：
10.1016/j.jgg.2022.03.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1162 / 1164
页数：3
相关论文
共 18 条
[1]   α+Thalassemia Antagonizes the Malaria-protective Effects of Sickle-Cell Trait [J].
Amaratunga, Chanaki ;
Fairhurst, Rick M. .
EBIOMEDICINE, 2014, 1 (01) :8-9
[2]   Genetic research and clinical analysis of β-globin gene cluster deletions in the Chinese population of Fujian province: A 14-year single-center experience [J].
Chen, Meihuan ;
Zhang, Min ;
Chen, Lingji ;
Lin, Na ;
Wang, Yan ;
Xu, Liangpu ;
Huang, Hailong .
JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2022, 36 (02)
[3]   A novel fusion gene and a common α0-thalassemia deletion cause hemoglobin H disease in a Chinese family [J].
Huang, Ji-Wei ;
Shang, Xuan ;
Zhao, Ying ;
Cai, Ren ;
Zhang, Xin-Hua ;
Wei, Xiao-Feng ;
Xiong, Fu ;
Xu, Xiang-Min .
BLOOD CELLS MOLECULES AND DISEASES, 2013, 51 (01) :31-34
[4]   Human genetics and malaria resistance [J].
Kariuki, Silvia N. ;
Williams, Thomas N. .
HUMAN GENETICS, 2020, 139 (6-7) :801-811
[5]   How malaria has affected the human genome and what human genetics can teach us about malaria [J].
Kwiatkowski, DP .
AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 77 (02) :171-192
[6]   The prevalence of thalassemia in mainland China: evidence from epidemiological surveys [J].
Lai, Ketong ;
Huang, Guifeng ;
Su, Li ;
He, Yunyan .
SCIENTIFIC REPORTS, 2017, 7
[7]   Effect of red blood cell variants on childhood malaria in Mali: a prospective cohort study [J].
Lopera-Mesa, Tatiana M. ;
Doumbia, Saibou ;
Konate, Drissa ;
Anderson, Jennifer M. ;
Doumbouya, Mory ;
Keita, Abdoul S. ;
Diakite, Seidina A. S. ;
Traore, Karim ;
Krause, Michael A. ;
Diouf, Ababacar ;
Moretz, Samuel E. ;
Tullo, Gregory S. ;
Miura, Kazutoyo ;
Gu, Wenjuan ;
Fay, Michael P. ;
Taylor, Steve M. ;
Long, Carole A. ;
Diakite, Mahamadou ;
Fairhurst, Rick M. .
LANCET HAEMATOLOGY, 2015, 2 (04) :E140-E149
[8]   2021 update on clinical trials in β-thalassemia [J].
Musallam, Khaled M. ;
Bou-Fakhredin, Rayan ;
Cappellini, Maria Domenica ;
Taher, Ali T. .
AMERICAN JOURNAL OF HEMATOLOGY, 2021, 96 (11) :1518-1531
[9]   Rapid Targeted Next-Generation Sequencing Platform for Molecular Screening and Clinical Genotyping in Subjects with Hemoglobinopathies [J].
Shang, Xuan ;
Peng, Zhiyu ;
Ye, Yuhua ;
Asan ;
Zhang, Xinhua ;
Chen, Yan ;
Zhu, Baosheng ;
Cai, Wangwei ;
Chen, Shaoke ;
Cai, Ren ;
Guo, Xiaoling ;
Zhang, Chonglin ;
Zhou, Yuqiu ;
Huang, Shuodan ;
Liu, Yanhui ;
Chen, Biyan ;
Yan, Shanhuo ;
Chen, Yajun ;
Ding, Hongmei ;
Yin, Xiaolin ;
Wu, Liusong ;
He, Jing ;
Huang, Dongai ;
He, Sheng ;
Yan, Tizhen ;
Fan, Xin ;
Zhou, Yuehong ;
Wei, Xiaofeng ;
Zhao, Sumin ;
Cai, Decheng ;
Guo, Fengyu ;
Zhang, Qianqian ;
Li, Yun ;
Zhang, Xuelian ;
Lu, Haorong ;
Huang, Huajie ;
Guo, Junfu ;
Zhu, Fei ;
Yuan, Yuan ;
Zhang, Li ;
Liu, Na ;
Li, Zhiming ;
Jiang, Hui ;
Zhang, Qiang ;
Zhang, Yijia ;
Juhari, Wan Khairunnisa Wan ;
Hanafi, Sarifah ;
Zhou, Wanjun ;
Xiong, Fu ;
Yang, Huanming .
EBIOMEDICINE, 2017, 23 :150-159
[10]   Thalassaemia [J].
Taher, Ali T. ;
Weatherall, David J. ;
Cappellini, Maria Domenica .
LANCET, 2018, 391 (10116) :155-167
12