Changes in circulating dendritic cells and B-cells in patients with multiple sclerosis relapse during corticosteroid therapy

被引：7

作者：

Krystyna, Mitosek-Szewczyk ^{[1
]}

Jacek, Tabarkiewicz ^{[2
]}

Sebastian, Radej ^{[2
]}

Ewa, Belniak ^{[1
]}

Halina, Bartosik-Psujek ^{[1
]}

Zbigniew, Stelmasiak ^{[1
]}

Jacek, Rolinski ^{[2
]}

机构：

[1] Med Univ Lublin, Dept Neurol, PL-20090 Lublin, Poland

[2] Med Univ Lublin, Dept Immunol, PL-20090 Lublin, Poland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 207卷 / 1-2期

关键词：

Dendritic cells; B cell; Multiple sclerosis; Methyloprednisolone; DIFFERENTIATION; PATHOGENESIS; SUBSETS;

D O I：

10.1016/j.jneuroim.2008.11.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied dendritic, myeloid (mDCs) (BDCA1+/CD19-) and plasmacytoid cells (pDCs) (BDCA2+/CD123+) and B-cells (CD19+) at relapse, after short intravenous methyloprednisolone therapy and 30 days after treatment completion (remission period) and results were compared with a control group of healthy volunteers. We confirmed the decrease in BDCA2+/CD723+ after therapy (p=0.00006) and then an increase (p=0.0032) in comparison to the control group. The level of B CD19+ cells after GC therapy increased compared to the control group (p=0.00809) and had stabilised 30 days after therapy. The effect of methyloprednisolone on DC function and B-cell levels thus changes. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：107 / 110

页数：4

共 13 条

[1] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[2] Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis [J].

Corcione, A ;

Casazza, S ;

Ferretti, E ;

Giunti, D ;

Zappia, E ;

Pistorio, A ;

Gambini, C ;

Mancardi, GL ;

Uccelli, A ;

Pistoia, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (30) :11064-11069

[3]

Duddy M, 2006, Int MS J, V13, P84

[4] Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis [J].

Duddy, Martin ;

Niino, Masaaki ;

Adatia, Femina ;

Hebert, Sherry ;

Freedman, Mark ;

Atkins, Harry ;

Kim, Ho Jin ;

Bar-Or, Amit .

JOURNAL OF IMMUNOLOGY, 2007, 178 (10) :6092-6099

[5]

KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444

[6]

Lucchinetti C, 2000, ANN NEUROL, V47, P707, DOI 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO

[7]

2-Q

[8] Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis [J].

McDonald, WI ;

Compston, A ;

Edan, G ;

Goodkin, D ;

Hartung, HP ;

Lublin, FD ;

McFarland, HF ;

Paty, DW ;

Polman, CH ;

Reingold, SC ;

Sandberg-Wollheim, M ;

Sibley, W ;

Thompson, AJ ;

van den Noort, S ;

Weinshenker, BY ;

Wolinsky, JS .

ANNALS OF NEUROLOGY, 2001, 50 (01) :121-127

[9] Circulating dendritic cells subsets and regulatory T-cells at multiple sclerosis relapse:: Differential short-term changes on corticosteroids therapy [J].

Navarro, Joaquin ;

Aristimuno, Carol ;

Sanchez-Ramon, Silvia ;

Vigil, Dolores ;

Martinez-Gines, Ma. Luisa ;

Fernandez-Cruz, Eduardo ;

de Andres, Clara .

JOURNAL OF NEUROIMMUNOLOGY, 2006, 176 (1-2) :153-161

[10] Role of B cells in pathogenesis of multiple sclerosis [J].

Nikbin, Behrouz ;

Bonab, Mandana Mohyeddin ;

Khosravi, Farideh ;

Talebian, Fatemeh .

NEUROBIOLOGY OF MULTIPLE SCLEROSIS, 2007, 79 :13-+

← 1 2 →